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Dermatology Research and Practice
Volume 2017, Article ID 4137597, 7 pages
https://doi.org/10.1155/2017/4137597
Research Article

Ischaemic Preconditioning Suppresses Necrosis of Adipocutaneous Flaps in a Diabetic Rat Model Regardless of the Manner of Preischaemia Induction

1Unfallkrankenhaus Berlin, Center for Severe Burn Injuries with Plastic Surgery, Berlin, Germany
2Evangelical Elisabeth Clinic, Berlin, Germany
3Walter Reed Army Institute of Research, Silver Spring, MD, USA

Correspondence should be addressed to Christian Ottomann; ed.oohay@ed1071otto

Received 7 June 2017; Accepted 18 September 2017; Published 18 October 2017

Academic Editor: Lajos Kemény

Copyright © 2017 Christian Ottomann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Hill, G. Zalos, J. P. J. Halcox et al., “Circulating endothelial progenitor cells, vascular function, and cardiovascular risk,” The New England Journal of Medicine, vol. 348, no. 7, pp. 593–600, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. G. K. Kolluru, S. C. Bir, and C. G. Kevil, “Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing,” International Journal of Vascular Medicine, vol. 2012, Article ID 918267, 30 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Schürmann, O. Seitz, R. Sader, J. Pfeilschifter, I. Goren, and S. Frank, “Role of wound macrophages in skin flap loss or survival in an experimental diabetes model,” British Journal of Surgery, vol. 97, no. 9, pp. 1437–1451, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. N. NIDDK, “National diabetes statistics report,” 2014, https://www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf.
  5. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King, “Global prevalence of diabetes: estimates for the year 2000 and projections for 2030,” Diabetes Care, vol. 27, no. 5, pp. 1047–1053, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. K. S. Zahir, S. A. Syed, J. R. Zink, R. J. Restifo, and J. G. Thomson, “Ischemic preconditioning improves the survival of skin and myocutaneous flaps in a rat model,” Plastic and Reconstructive Surgery, vol. 102, no. 1, pp. 140–152, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. T. M. Zahir, K. S. Zahir, S. A. Syed, R. J. Restifo, and J. Grant Thomson, “Ischemic preconditioning of musculocutaneous flaps: Effects of ischemia cycle length and number of cycles,” Annals of Plastic Surgery, vol. 40, no. 4, pp. 430–435, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. C. M. A. Carroll, S. M. Carroll, M. L. E. Overgoor, G. Tobin, and J. H. Barker, “Acute ischemic preconditioning of skeletal muscle prior to flap elevation augments muscle-flap survival,” Plastic and Reconstructive Surgery, vol. 100, no. 1, pp. 58–65, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. M. V. Küntscher, T. Kastell, H. Engel, M. M. Gebhard, C. Heitmann, and G. Germann, “Late remote ischemic preconditioning in rat muscle and adipocutaneous flap models,” Annals of Plastic Surgery, vol. 51, no. 1, pp. 84–90, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Yue, P. Zhang, D. Liu, J. F. Yang, C. Nie, and D. Yang, “Hypoxia preconditioning enhances the viability of ADSCs to increase the survival rate of ischemic skin flaps in rats,” Aesthetic Plastic Surgery, vol. 37, no. 1, pp. 159–170, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Zarbock, C. Schmidt, H. Van Aken et al., “Effect of remote ischemic preconditioning on kidney injury among high-risk patients undergoing cardiac surgery: A randomized clinical trial,” Journal of the American Medical Association, vol. 313, no. 21, pp. 2133–2141, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. I. Saeki, T. Matsuura, M. Hayashida, and T. Taguchi, “Ischemic preconditioning and remote ischemic preconditioning have protective effect against cold ischemia-reperfusion injury of rat small intestine,” Pediatric Surgery International, vol. 27, no. 8, pp. 857–862, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Wang, J. Shen, X. Xiong et al., “Remote ischemic preconditioning protects against liver ischemia-reperfusion injury via heme oxygenase-1-induced autophagy,” PLoS ONE, vol. 9, no. 6, Article ID e98834, 2014. View at Publisher · View at Google Scholar
  14. Z. Hu, S. Hu, S. Yang et al., “Remote liver ischemic preconditioning protects against sudden cardiac death via an ERK/GSK-3β-dependent mechanism,” PLoS ONE, vol. 11, no. 10, Article ID e0165123, 2016. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Peralta, D. Closa, G. Hotter, E. Gelpí, N. Prats, and J. Roselló-Catafau, “Liver ischemic preconditioning is mediated by the inhibitory action of nitric oxide on endothelin,” Biochemical and Biophysical Research Communications, vol. 229, no. 1, pp. 264–270, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. M. V. Küntscher, S. Juran, J. Altmann, H. Menke, M. M. Gebhard, and G. Germann, “Role of Nitric Oxide in the Mechanism of Preclamping and Remote Ischemic Preconditioning of Adipocutaneous Flaps in a Rat Model,” Journal of Reconstructive Microsurgery, vol. 19, no. 1, pp. 055–060, 2003. View at Publisher · View at Google Scholar
  17. M. V. Küntscher, T. Kastell, J. Altmann, H. Menke, M. M. Gebhard, and G. Germann, “Acute remote ischemic preconditioning II: The role of nitric oxide,” Microsurgery, vol. 22, no. 6, pp. 227–231, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Masaoka, H. Asato, K. Umekawa, M. Imanishi, and A. Suzuki, “Value of remote ischaemic preconditioning in rat dorsal skin flaps and clamping time,” Journal of Plastic Surgery and Hand Surgery, vol. 50, no. 2, pp. 107–110, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Akcal, S. S. Sirvan, S. Karsidag et al., “Combination of ischemic preconditioning and postconditioning can minimise skin flap loss: experimental study,” Journal of Plastic Surgery and Hand Surgery, vol. 50, no. 4, pp. 233–238, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. O. K. Coskunfirat, A. Cinpolat, G. Bektas, O. Ogan, and T. Taner, “Comparing different postconditioning cycles after ischemia reperfusion injury in the rat skin flap,” Annals of Plastic Surgery, vol. 72, no. 1, pp. 104–107, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Kraemer, J. Lorenzen, M. Kabbani et al., “Acute effects of remote ischemic preconditioning on cutaneous microcirculation - A controlled prospective cohort study,” BMC Surgery, vol. 11, article no. 32, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. M. M. Galagudza, M. K. Nekrasova, A. V. Syrenskii, and E. M. Nifontov, “Resistance of the myocardium to ischemia and the efficacy of ischemic preconditioning in experimental diabetes mellitus,” Neuroscience and Behavioral Physiology, vol. 37, no. 5, pp. 489–493, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. P. G. Cordeiro, J. J. Lee, D. Mastorakos, Q. Y. Hu, J. T. Pinto, and E. Santamaria, “Prevention of Ischemia-Reperfusion Injury in a Rat Skin Flap Model: The Role of Mast Cells, Cromolyn Sodium, and Histamine Receptor Blockade,” Plastic and Reconstructive Surgery, vol. 105, no. 2, pp. 654–659, 2000. View at Publisher · View at Google Scholar
  24. P. G. Cordeiro, D. P. Mastorakos, Q.-Y. Hu, and R. E. Kirschner, “The protective effect of L-arginine on ischemia-reperfusion injury in rat skin flaps,” Plastic and Reconstructive Surgery, vol. 100, no. 5, pp. 1227–1233, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Genovese, E. Mazzon, I. Paterniti, E. Esposito, P. Bramanti, and S. Cuzzocrea, “Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats,” Brain Research, vol. 1372, pp. 92–102, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. Q. Yang, G. W. He, Underwood M. J., and C. M. Yu, “Cellular and molecular mechanisms of endothelial ischemia/reperfusion injury: perspectives and implications for postischemic myocardial protection,” American Journal of Translational Research, vol. 8, no. 2, pp. 765–777, 2016. View at Google Scholar
  27. E. A. Kocman, O. Ozatik, A. Sahin et al., “Effects of ischemic preconditioning protocols on skeletal muscle ischemia-reperfusion injury,” Journal of Surgical Research, vol. 193, no. 2, pp. 942–952, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. F. W. Blaisdell, “The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review,” Cardiovascular Surgery, vol. 10, no. 6, pp. 620–630, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Fernandez-Jimenez, J. Sánchez-González, J. Agüero et al., “Myocardial edema after ischemia/reperfusion is not stable and follows a bimodal pattern: imaging and histological tissue characterization,” Journal of the American College of Cardiology, vol. 65, no. 4, pp. 315–323, 2015. View at Google Scholar
  30. A. L. Emanuel, M. D. Nieuwenhoff, E. S. Klaassen et al., “Relationships between type 2 diabetes, neuropathy, and microvascular dysfunction: evidence from patients with cryptogenic axonal polyneuropathy,” Diabetes Care, vol. 40, no. 4, pp. 583–590, 2017. View at Publisher · View at Google Scholar
  31. K. Igari, T. Kudo, H. Uchiyama, T. Toyofuku, and Y. Inoue, “Quantitative evaluation of microvascular dysfunction in peripheral neuropathy with diabetes by indocyanine green angiography,” Diabetes Research and Clinical Practice, vol. 104, no. 1, pp. 121–125, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. H. O. Steinberg, H. Chaker, R. Leaming, A. Johnson, G. Brechtel, and A. D. Baron, “Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance,” The Journal of Clinical Investigation, vol. 97, no. 11, pp. 2601–2610, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Montagnani and M. J. Quon, “Insulin action in vascular endothelium: potential mechanisms linking insulin resistance with hypertension,” Diabetes, Obesity and Metabolism, vol. 2, no. 5, pp. 285–292, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. R. Muniyappa and M. J. Quon, “Insulin action and insulin resistance in vascular endothelium,” Current Opinion in Clinical Nutrition & Metabolic Care, vol. 10, no. 4, pp. 523–530, 2007. View at Publisher · View at Google Scholar · View at Scopus