From Localized Scleroderma to Systemic Sclerosis: Coexistence or Possible Evolution
Graphical representation of the LoS onset in 33 patients (25 cases from the literature plus our 8 cases) concerning SSc onset (coloured bars correspond to the time spans between LoS and SSc beginnings). LoS may appear before or after SSc diagnosis, mainly in a time period between −5 and +5 years from SSc onset (27/33, 81.8%). To note, in 5 patients LoS and SSc presented contemporarily (“”).
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