Research Article

Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital

Table 2

Clinical features of patients with Stevens-Johnson syndrome and overlap-toxic epidermal necrolysis.

SJS, N = 20Overlap-TEN, N = 16Overall, N = 36P value

Prodromal symptoms, N (%)15 (75.0)11 (68.8)26 (72.2)0.677
 Fever14 (70.0)11 (68.8)25 (69.4)0.352
 Stinging eye4 (20.0)4 (25.0)8 (22.2)0.477
 Sore throat5 (25.0)1 (6.2)6 (16.7)0.274

Cutaneous findings at the presentation, N (%)
 Morbilliform rash19 (95.0)11 (68.8)30 (83.3)0.036
 Blister5 (25.0)9 (56.3)14 (38.9)0.056
 Targetoid lesions6 (30.0)3 (18.8)9 (25.0)0.439
 Purpuric macules1 (5.0)01 (2.8)0.364

Mucosal involvement, N (%)
 Oral19 (95.0)16 (100.0)35 (97.2)0.364
 Eye17 (85.0)13 (81.2)30 (83.3)0.764
 Genital15 (75.0)11 (68.8)26 (72.2)0.677
 Anus3 (15.0)3 (18.8)6 (16.7)0.764

Associated abnormalities
 GI abnormalities9 (45.0)9 (56.3)18 (50.0)0.502
  Transaminitis9 (45.0)9 (56.3)18 (50.0)0.645
  Direct hyperbilirubinemia3 (15.0)03 (8.3)0.106
 Electrolyte abnormalities8 (40.0)8 (50.0)13 (44.4)0.568
  Hyponatremia5 (25.0)3 (18.8)8 (22.2)0.654
  Hypokalemia3 (15.0)4 (25.0)7 (19.4)0.451
  Hypocalcemia, hypophosphatemia01 (6.2)1 (2.8)0.257
 Renal abnormalities1 (5.0)1 (6.2)2 (5.6)0.359
  Rising creatinine1 (5.0)01 (2.8)0.364
  Rising creatinine and hematuria01 (6.2)1 (2.8)0.257

Significant values are shown in bold.