Dermatology Research and Practice

From Melanocyte to Malignant Metastatic Melanoma

Publishing date
01 Sep 2010
Submission deadline
01 Mar 2010

Lead Editor

1Departments of Dermatology and Cell Biology, New York University, NY, USA

2Department Human Biology, University of Cape Town Medical School, Cape Town, South Africa

3Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland

4Department of Dermatology, University of Utah, Salt Lake, UT, USA

From Melanocyte to Malignant Metastatic Melanoma


Incidence of melanoma, the deadliest form of skin cancer, continues to increase among older adults and young women worldwide despite significant efforts to inform the public about risk factors such as sun exposure and the need to monitor skin for potential neoplastic lesions. While mortality rates have stabilized in the US, first-line chemotherapeutic and radiation treatment of metastatic melanoma remains largely ineffective, highlighting the need to better understand the mechanisms underlying disease initiation and progression. Melanoma results from malignant transformation of melanocytes. The most frequent site of transformation is in the skin where melanocytes produce the pigment melanin that confers skin color and protects against sun-induced damage. Multiple factors contribute to melanoma risk, including genetic predisposition and environmental risk factors such as sun exposure. The focus of this special issue will be on the mechanisms underlying melanocyte transformation and progression from localized to metastatic disease. We welcome authors to submit original research articles, review articles, case reports, and clinical studies that address these issues. The topics to be covered include, but are not limited to:

  • Melanoma epidemiology
    • Genetic risk factors for sporadic melanoma
      • Functional analysis of genes associated with risk of melanoma
      • Genome-wide and candidate gene association studies
    • UV exposure and melanoma
      • Melanocyte response to UV exposure
  • Public education
    • Prevention strategies to reduce melanoma incidence
  • Biology of melanocyte transformation
    • Changing expression profiles during melanocyte transformation
  • Mechanisms underlying progression to metastatic malignant melanoma
  • Clinical management of patients at risk of melanoma
  • Diagnostic approaches
    • Morphological (clinical, dermoscopical, and histopathological) aspects of melanoma development
  • Novel approaches to treatment of melanoma
    • Personalized treatment of melanoma based on genetic profiling of tumors

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2010
  • - Article ID 798324
  • - Editorial

From Melanocyte to Malignant Metastatic Melanoma

Prashiela Manga | Keith S. Hoek | ... | Sancy A. Leachman
  • Special Issue
  • - Volume 2010
  • - Article ID 583748
  • - Review Article

From Melanocyte to Metastatic Malignant Melanoma

Bizhan Bandarchi | Linglei Ma | ... | Golnar Rasty
  • Special Issue
  • - Volume 2010
  • - Article ID 839829
  • - Research Article

The Determination of Melanoma Stage at Diagnosis

John A. H. Lee
  • Special Issue
  • - Volume 2010
  • - Article ID 657406
  • - Review Article

Metastatic Melanomas Express Inhibitory Low Affinity Fc Gamma Receptor and Escape Humoral Immunity

Joel F. G. Cohen-Solal | Lydie Cassard | ... | Catherine Sautès-Fridman
  • Special Issue
  • - Volume 2010
  • - Article ID 185687
  • - Review Article

Angiogenesis and Progression in Human Melanoma

R. Ria | A. Reale | ... | A. Vacca
  • Special Issue
  • - Volume 2010
  • - Article ID 360136
  • - Review Article

Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind?

Thomas van den Bosch | Emine Kilic | ... | Annelies de Klein
  • Special Issue
  • - Volume 2010
  • - Article ID 483493
  • - Review Article

Stress as a Possible Mechanism in Melanoma Progression

M. Sanzo | R. Colucci | ... | S. Moretti
Dermatology Research and Practice
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