The Strategy of Combining Antidepressants in the Treatment of Major Depression: Clinical Experience in Spanish Outpatients

Table 5

Comparative study of Hamilton basal score one AD versus combination.

Hamilton D-17 items	One AD	Dt	Combination	dt	𝑃≤.05
(1) Depressed mood	2.58	.77	2.76	.93	+
(2) Feelings of guilt	1.29	.88	1.24	.91	−
(3) Suicidal ideation	1.14	.96	1.11	1.03	−
(4) Early insomnia	1.49	.65	1.48	.72	−
(5) Middle insomnia	1.09	.63	1.05	.58	−
(6) Late insomnia	1.09	.75	1.08	.67	−
(7) Work and activities	2.37	.85	2.47	.94	−
(8) Retardation	1.06	.85	1.14	.85	−
(9) Agitation	1.14	.86	1.17	.77	−
(10) Psychic anxiety	2.08	.89	2.16	.82	−
(11) Somatic anxiety	1.86	.78	1.89	.76	−
(12) Somatic symptoms (gastrointestinal)	1.05	.64	.89	.65	−
(13) Somatic symptoms general	1.25	.55	1.17	.02	+
(14) Reduced libido	0.91	0.76	1.03	.78	−
(15) Hypochondriasis	1.30	.97	1.25	1.02	−
(16) Insight into illness	.31	.50	.19	.39	−
(17) Loss of weight	.70	.70	.41	.00	+
Total	22.67	5.91	22.34	5.52	−