Efficacy of Chronic Antidepressant Treatments in a New Model of Extreme Anxiety in Rats

Table 5

Effects of acute clonazepam (CZP) treatment (1 mg/kg, IP, 𝑛=9, median with limits of interquartile range values). Mann-Whitney U test: *𝑃<0.05; **𝑃<0.01 (CZP versus vehicle). Wilcoxon-test: ^#𝑃≤0.05; ^##𝑃<0.01 (test versus baseline). Data were expressed as median with limits of interquartile range values.

Measures	Baseline (before treatment)		Test (after treatment)
	Vehicle (𝑛=9)	CZP (𝑛=9)	Vehicle (𝑛=9)	CZP (𝑛=9)
Number of jumps	17 (9.75–21.75)	15 (11–17)	18 (15.25–20.5)	3^**## (2–8)
Latency before the first jump (s)	14 (6.5–35.75)	12 (4.5–19.5)	10 (7.25–31)	68^*# (20.5–75)
Immobility (s)	90 (50–133.5)	85 (65.25–115)	130^# (92–162)	125^# (104–145.5)