Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses

Figure 2

Schematic structures of AKT1, PTEN, and mTOR protein. The predicted consensual domain structures for each protein are depicted. The functionally important sites including the sites of protein phosphorylation are also shown. Note that the sizes of protein are modified for clarity. PH domain: pleckstrin homology domain; C2 domain: a protein structural domain involved in targeting proteins to cell membranes; PDZ: a common structural domain in signaling proteins (PSD95, Dlg, ZO-1, etc.); HEAT: huntington, elongation factor 3, a subunit of PP2A, and TOR1; FAT: FRAP-ATM-TRRAP; FRB: FKBP12-rapamycin binding; FATC: FAT-C-terminal.