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Depression Research and Treatment
Volume 2012 (2012), Article ID 860745, 11 pages
Research Article

Quality of Life in Bipolar Type I Disorder in a One-Year Followup

1Department of Psychiatry, Roozbeh Hospital, South Kargar Avenue, Tehran 1333795914, Iran
2Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran 1333795914, Iran

Received 12 June 2012; Revised 10 December 2012; Accepted 13 December 2012

Academic Editor: Janusz K. Rybakowski

Copyright © 2012 Homayoun Amini and Vandad Sharifi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. The aims of this study were (i) to compare Quality of Life (QOL) of patients with bipolar disorder (BD) type I to those with schizophrenia during a one-year period after hospitalization and (ii) to assess the association of different domains of QOL with severity of clinical symptoms and level of functioning in bipolar patients group. Method. A hundred and two participants were consecutively recruited before discharge from an acute hospitalization. To measure QOL as the main outcome variable, the Farsi (Persian) version of the World Health Organization's QOL Instrument Short Version (WHOQOL BREF) was used. Affective symptoms, overall functioning, and severity of mental illness were assessed as well. The assessment procedure was repeated four, eight, and 12 months after discharge. Results. No significant differences were found between patients with BD and schizophrenia on four domains of WHOQOL BREF at the baseline and the four, eight, and 12 month assessments. Within the subjects with bipolar I disorder, the most stable finding was negative association of depression severity with WHOQOL-BREF on the all four domains during repeated assessments. Conclusion. The findings suggest that persistent depressive symptoms might be the primary determinant of impaired QOL in patients with bipolar I disorder.