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Depression Research and Treatment
Volume 2013, Article ID 256841, 8 pages
http://dx.doi.org/10.1155/2013/256841
Review Article

Reduced Treatment-Emergent Sexual Dysfunction as a Potential Target in the Development of New Antidepressants

1Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton SO14 3DT, UK
2Department of Psychiatry, University of Cape Town, Cape Town, South Africa
3Department of Pathophysiology and Transplantation, University of Milan and Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy
4First Department of Psychiatry, Eginition Hospital, Athens University Medical School, 11528 Athens, Greece

Received 1 October 2012; Revised 18 December 2012; Accepted 3 January 2013

Academic Editor: Charles B. Nemeroff

Copyright © 2013 David S. Baldwin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [15 citations]

The following is the list of published articles that have cited the current article.

  • G. Giupponi, A. La Torre, D. Duffy, and A. Conca, “Sexual Dysfunction Related to Psychotropic Drugs: A Critical Review - Part I: Antidepressants,” Pharmacopsychiatry, vol. 46, no. 5, pp. 191–199, 2013. View at Publisher · View at Google Scholar
  • Pierre Blier, “Neurotransmitter Targeting in the Treatment of Depression,” Journal of Clinical Psychiatry, vol. 74, pp. 19–24, 2013. View at Publisher · View at Google Scholar
  • Petra M. Casey, Stephanie S. Faubion, Kathy L. MacLaughlin, Margaret E. Long, and Sandhya Pruthi, “Caring for the breast cancer survivor's health and wellbeing,” World Journal of Clinical Oncology, vol. 5, no. 4, pp. 693–704, 2014. View at Publisher · View at Google Scholar
  • Richard Balon, “Burden of sexual dysfunction,” Journal of Sex & Marital Therapy, pp. 00–00, 2015. View at Publisher · View at Google Scholar
  • David S. Baldwin, Chris Manson, and Magda Nowak, “Impact of Antidepressant Drugs on Sexual Function and Satisfaction,” Cns Drugs, vol. 29, no. 11, pp. 905–913, 2015. View at Publisher · View at Google Scholar
  • Angel L. Montejo, Laura Montejo, and Felipe Navarro-Cremades, “Sexual side-effects of antidepressant and antipsychotic drugs,” Current Opinion in Psychiatry, vol. 28, no. 6, pp. 418–423, 2015. View at Publisher · View at Google Scholar
  • Paula L. Jacobsen, Atul R. Mahableshwarkar, Yinzhong Chen, Lambros Chrones, and Anita H. Clayton, “Effect of Vortioxetine vs. Escitalopram on Sexual Functioning in Adults with Well-Treated Major Depressive Disorder Experiencing SSRI-Induced Sexual D,” Journal Of Sexual Medicine, vol. 12, no. 10, pp. 2036–2048, 2015. View at Publisher · View at Google Scholar
  • Heiko Graf, Maike Wiegers, Coraline D. Metzger, Martin Walter, Georg Groen, and Birgit Abler, “Erotic Stimulus Processing under Amisulpride and Reboxetine: A Placebo-Controlled fMRI Study in Healthy Subjects,” International Journal Of Neuropsychopharmacology, vol. 18, no. 2, 2015. View at Publisher · View at Google Scholar
  • Anita H. Clayton, Andrew R. Alkis, Nishant B. Parikh, and Jennifer G. Votta, “Sexual Dysfunction Due to Psychotropic Medications,” Psychiatric Clinics of North America, 2016. View at Publisher · View at Google Scholar
  • Atul R. Mahableshwarkar, Paula L. Jacobsen, William A. Palo, Yinzhong Chen, Marianne Dragheim, and Anita H. Clayton, “Treatment-emergent sexual dysfunction in randomized trials of vortioxetine for major depressive disorder or generalized anxiety disorder: A pooled analysis,” CNS Spectrums, vol. 21, no. 5, pp. 367–378, 2016. View at Publisher · View at Google Scholar
  • Seetal Dodd, Madhukar H. Trivedi, Maurizio Fava, A. John Rush, Roger S. McIntyre, Raymond W. Lam, Emanuel Severus, Michael Bauer, Lakshmi Yatham, Lana Williams, Michael E. Thase, Siegfried Kasper, Michael Berk, Philip B. Mitchell, Allan H. Young, Sidney H. Kennedy, Trisha Suppes, and Carlos Lopez Jaramillo, “Monitoring for antidepressant-associated adverse events in the treatment of patients with major depressive disorder: An international consensus statement,” World Journal of Biological Psychiatry, pp. 1–19, 2017. View at Publisher · View at Google Scholar
  • Stephen A. Adefegha, Sunday I. Oyeleye, Felix A. Dada, Tosin A. Olasehinde, and Ganiyu Oboh, “Modulatory effect of quercetin and its glycosylated form on key enzymes and antioxidant status in rats penile tissue of paroxetine-induced erectile dysfunction,” Biomedicine & Pharmacotherapy, vol. 107, pp. 1473–1479, 2018. View at Publisher · View at Google Scholar
  • Angel L. Montejo, Laura Montejo, and David S. Baldwin, “The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management,” World Psychiatry, vol. 17, no. 1, pp. 3–11, 2018. View at Publisher · View at Google Scholar
  • Angel L. Montejo, Joemir Becker, Gloria Bueno, Raquel Fernández-Ovejero, María T. Gallego, Nerea González, Adrián Juanes, Laura Montejo, Antonio Pérez-Urdániz, Nieves Prieto, and José L. Villegas, “Frequency of Sexual Dysfunction in Patients Treated with Desvenlafaxine: A Prospective Naturalistic Study,” Journal of Clinical Medicine, vol. 8, no. 5, pp. 719, 2019. View at Publisher · View at Google Scholar
  • Ayokunle O. Ademosun, Adeniyi A. Adebayo, and Ganiyu Oboh, “Anogeissus leiocarpus attenuates paroxetine-induced erectile dysfunction in male rats via enhanced sexual behavior, nitric oxide level and antioxidant status,” Biomedicine & Pharmacotherapy, vol. 111, pp. 1029–1035, 2019. View at Publisher · View at Google Scholar