Table of Contents
Diagnostic and Therapeutic Endoscopy
Volume 3, Issue 3, Pages 127-145

lmmuno Histochemical Profile of Endometrium in Patients With Genital Endometriosis

1Department of Obstetrics and Gynecology, University of Kiel Michaelisstrasse 16, Kiel 24105, Germany
2Institute of Cytopathology, University of Kiel Michaelisstrasse 16, Kiel 24105, Germany
3Research Centre of Obstetrics, Gynecology and Perinatology, Oparin Street, Moscow 117815, Russia
4Institute of Pathology, University of Kiel Michaelisstrasse 11, Kiel 24105, Germany

Received 29 January 1996; Revised 17 June 1996; Accepted 3 July 1996

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of present study was to investigate the occurence of different lymphocyte subsets in the endometrium of endometriosis patients and in healthy women on every day of the menstrual cycle with special emphasis to the proliferative activity of endometrial cells with Ki-S3 antibody. We also conducted immunohistochemical studies of T-lymphocytes, B-lympho-cytes, macrophages, natural-killer-cells and also of antigens class II of the histocompatibility complex (HLA-DR) during the different phases of the menstrual cycle in endometriosis and non-endometriosis patients.

Endometrial lymphocyte subsets show equal quantity and distribution in endometriosis patients and in the control group. After a peak in the early preoliferative phase the absolute number of T-lymphocytes decreases while a predominance of T-suppressor/cytotoxic T-lymphocytes (CD8) compared to T-helper/inducer lymphocytes (CD4) occurs towards the end of the menstrual cycle.

It can be concluded that endometrium as the potential parent epithelia of endometriotic lesions seems not to be altered in its lymphatic cell content compared to healthy women. Furthermore endometrium is clearly characterised as part of the mucosa associated lymphatic tissue (MALT). T-lymphocytes show specific quantitative changes due to different phases of the menstrual cycle.