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Diagnostic and Therapeutic Endoscopy
Volume 4, Issue 4, Pages 165-171
http://dx.doi.org/10.1155/DTE.4.165

Cooperative Clinical Trial of Photodynamic Therapy for Early Gastric Cancer With Photofrin Injection® and YAG-OPO Laser

1Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537, Japan
2Department of Gastroenterology, Chiba Nishi General Hospital, Japan
3Department of lnternal Medicine, University of Tsukuba, Japan
4Second Department of Surgery, Wakayama Medical School, Japan
5Department of Gastrointestinal Endoscopy, Tokyo Women's Medical College, Japan
6Second Department of Surgery, Chiba University, Japan
7Department of Endoscopic Diagnostics and Therapeutics, Chiba University, Japan
8Department of Gastroenterology, Tokyo Women's Medical College, Japan
9Margins Department of Surgery, Tokyo Medical College, Japan

Received 1 June 1997; Accepted 29 September 1997

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Objective: Photodynamic therapy (PDT) treats malignant tumors using photosensitizers and light. We employed a new pulse laser as the excitation light source for PDT, i.e. an optical parametric oscillator (OPO) system pumped by a Q-switched Nd:YAG laser, because it provides extremely high peak power.

Study Design/Materials and Methods: The effects of PDT using the photosensitizer Photofrin® and the new laser were evaluated in 12 patients with early gastric cancer.

Results: Complete responses (CR) were obtained in 75% of 12 assessable patients, CR was observed in all cases with mucosal carcinoma (response rate 100%).

Regarding toxicity, mild photosensitivity was seen in one case and it lasted several weeks. The other major side effect was decrease of total protein, which was observed in six patients (40%), lasting several months. There were no serious abnormalities in symptoms or laboratory tests.

Conclusion: We conclude that the YAG-OPO laser is suitable as an excitation light source for PDT.