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Diagnostic and Therapeutic Endoscopy
Volume 6 (2000), Issue 4, Pages 169-177
http://dx.doi.org/10.1155/DTE.6.169

Study of Superficial Type Colorectal Neoplasms With Central Depression

Division of Digestive Endoscopy, Ohashi Hospital, Toho University School of Medicine, 2-17-6 Ohashi, Meguro-ku, Tokyo 153-8515, Japan

Received 16 November 1999; Revised 12 January 2000; Accepted 16 March 2000

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Superficial lesion with central depression obtained by endoscopic resection (23 carcinomas limited in the mucosa and 40 adenomas) were studied morphologically and histologically. These lesions were calculated concerning the height from the muscularis mucosa, depth of depressed central portions and the height of circumferential mucosa. Then, using the image analyzer, followings were determined with two-dimensional analysis: (1) the size of neoplasms and also (2) the size of whole mucosal lesions which was calculated by drawing a perpendicular from the border of the neoplasms; and thus, the ratio of each area was calculated.

Little difference was found between the adenomas and carcinomas. The sizes of carcinomas were found to be of 8.8 ± 4.7 mm and the adenomas of 5.1 ± 2.3 mm (p < 0.01). As for the depth of depression, it was found to be of 352 ± 147 μm in the carcinomas and 277 ± 93 μm in the adenomas (p < 0.05). Concerning the ratio of carcinomatous area in the mucosa, it was found to be 78 ± 10% in the carcinomas, while in the adenomas, it was found to be 70 ± 10% (p < 0.05).

Accordingly, it was found that compared with the adenomas, carcinomas showed significantly larger in size, deeper depression in configuration and the ratio of their size in the mucosa is rather high.