Clinical Study

Small-Bowel Capsule Endoscopy in Patients with Suspected Crohn's Disease—Diagnostic Value and Complications

Table 4

Value of different criteria in the diagnosis of CD.

Sens. (95%CI)Spec. (95%CI)PPV (95%CI)NPV (95%CI)LLR+ (95%CI)LLR− (95%CI)

Lesions on SBCE93 (75–98)80 (64–90)77 (59–88)94 (79–99)4.7 (2.5–8.9)0.08 (0.02–0.3)
ICCE criteria65 (45–81)58 (42–73)52 (35–69)70 (52–84)1.5 (1–2.4)0.58 (0.34–1)
plus lesions on SBCE100 (70–100)86 (64–96)85 (61–86)100 (79–100)7.3 (2.5–20)0
Symptoms plus extraint.symptoms/signs24 (11–43)70 (54–83)36 (17–61)56 (42–70)0.8 (0.3–1.8)1.0 (0.8–1.34)
plus lesions on SBCE77 (40–96)100 (80–100)100 (50–100)91 (70–98)(a)0.22 (0.06–0.7)
Symptoms plus abnormal imaging29 (13–51)91 (75–97)70 (35–91)65 (50–77)3.4 (0.9–11)0.77 (0.59–1)
plus lesions on SBCE100 (46–100)96 (80–99)83 (36–99)100 (84–100)29 (4,2–198)0
Symptoms plus Inflammatory markers55 (35–73)78 (61–88)64 (42–81)71 (55–83)2.5 (1.2–4.8)0.57 (0.37–0.8)
plus lesions on SBCE88 (863–98)96 (78–99)94 (69–99)92 (74–98)23.1 (3.3–159)0.1 (0.03–0.4)

Sens.: sensitivity; Spec.: specificity; PPV: positive predictive value; NPV: negative predictive value; LLR+: likelihood ratio positive; LLR−: likelihood ratio negative; CI: Confidence Interval; extraint.: extraintestinal; (a)infinity.