Endoscopic-Ultrasound-Guided Tissue Sampling Facilitates the Detection of Local Recurrence and Extra Pelvic Metastasis in Pelvic Urologic Malignancy

Table 1

Clinical and EUS features of patients with primary disease, local recurrence or extra pelvic metastatic urological disease.

	Age & gender	Prior cancer diagnosis	Referral source	FNA location	Targeted biopsy or incidental finding	FNA passes	Cytologic interpretation	Immuno-staining^1	Final diagnosis
1	84 M	Bladder	General surgery	Iliac LN	Targeted biopsy	5	Positive	CK7, CK20, OSCAR, p63	Recurrent bladder
2	82 M	Bladder (T1)	Colorectal surgery	Bladder mass	Incidental	3	Positive	CK7, CK20, CK903	Recurrent bladder
3	82 M	Bladder G3 muscle invasive	Urology	Perirectal space	Targeted biopsy	3	Positive	CK7, CK20	Recurrent bladder
4	64 M	No	Urology	Perirectal space	Targeted biopsy	1	Positive	NA	Bladder cancer
5	68 M	Prostate (T3b) & perianal Crohns disease	Urology	Perirectal space	Targeted biopsy	3	Negative	NA	Recurrent prostate following surgical evaluation
6	66 M	Prostate Gleason 3 + 3	Urology	Perirectal LN	Targeted biopsy	3	Positive	PSA, PACP	Recurrent prostate
7	77 M	Prostate Gleason 4 + 4	Urology	Perirectal LN	Targeted biopsy	5	Positive	PSA, PACP	Prostate cancer
8	95 M	Bladder G1	Gastroenterology	Perirectal LN	Targeted biopsy	3	Positive	PSA	Prostate cancer
9	60 M	Bladder	Gastroenterology	Rectal wall	Targeted biopsy	3	Suspicious	NA	Recurrent bladder³
10	53 M	Prostate Gleason 3 + 3	Urology	Perirectal space	Targeted biopsy	2	Positive	PSA, PACP	Recurrent prostate
11	73 M	Bladder G2 superficial	Urology	Rectal wall	Targeted biopsy	5	Positive	NA	Recurrent bladder³
12	54 M	Bladder G3 muscle invasive	Gastroenterology	Rectal wall	Targeted biopsy	3 & TCB (4)	Positive	CK7, CK20	Recurrent bladder³
13	54 M	No	Urology	Perirectal space	Targeted biopsy	4	Negative	NA	left seminal vesicle
14	55 M	Bladder G3 muscle invasive	Urology	Rectal wall	Targeted biopsy	2 & TCB (2)	Positive	CK7, CK20, CK903	Recurrent bladder³
15	70 F	Bladder G3 muscle invasive	Urology	Rectal wall	Targeted biopsy	9	Positive	Keratin AE1/AE3	Recurrent bladder
16	86 M	Prostate	Urology	Perirectal space	Targeted biopsy	2	Positive	NA	Recurrent prostate
17	40 M	Bladder G3 muscle invasive	Urology	Mediastinal LN	Targeted biopsy	4	Positive	NA	Metastatic bladder
18	37 M	Testicular embryonal and yolk sac tumor	Urology	Duodenal wall	Targeted biopsy	5 & TCB (3)	Positive	NA	Metastatic nonseminomatous germ cell tumor consistent with embryonal carcinoma
19	72 M	Prostate Gleason 3 + 3	Medical oncology	Subcarinal LN	Targeted biopsy	3	Positive	PSA, PACP^°	Metastatic prostate

¹CK7, 20, 903: Cytokeratin 7, 20, 903.
OSCAR: Monoclonal Antibody against Cytokeratin.
PSA: Prostate-specific antigen.
PACP: Human prostatic acid phosphatase.
Keratin AE1/AE3: detects CK1–8, 10, 14–16 and 19.
^°Negative for CK7, TTF-1 and CDX2.
²LN: lymph node.
³Linitis plastica.