Table of Contents
Diagnostic and Therapeutic Endoscopy
Volume 2013, Article ID 241320, 9 pages
http://dx.doi.org/10.1155/2013/241320
Review Article

The Current State of Diagnosis and Treatment for Early Gastric Cancer

1Department of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba 272-8516, Japan
2Department of Gastroenterology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan

Received 8 October 2012; Accepted 24 January 2013

Academic Editor: Tony C. K. Tham

Copyright © 2013 Tomoyuki Yada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, R. Siegel, J. Xu, and E. Ward, “Cancer statistics, 2010,” CA Cancer Journal for Clinicians, vol. 60, no. 5, pp. 277–300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Ferlay, H. R. Shin, F. Bray, D. Forman, C. Mathers, and D. M. Parkin, “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008,” International Journal of Cancer, vol. 127, no. 12, pp. 2893–2917, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Hamashima, D. Shibuya, H. Yamazaki et al., “The Japanese guidelines for gastric cancer screening,” Japanese Journal of Clinical Oncology, vol. 38, no. 4, pp. 259–267, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Maruyama, M. Kaminishi, K. I. Hayashi et al., “Gastric cancer treated in 1991 in Japan: data analysis of nationwide registry,” Gastric Cancer, vol. 9, no. 2, pp. 51–66, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Ono, H. Kondo, T. Gotoda et al., “Endoscopic mucosal resection for treatment of early gastric cancer,” Gut, vol. 48, no. 2, pp. 225–229, 2001. View at Google Scholar
  6. F. J. Oliveira, H. Ferrao, E. Furtado, H. Batista, and L. Conceicao, “Early gastric cancer: report of 58 cases,” Gastric Cancer, vol. 1, no. 1, pp. 51–56, 1998. View at Google Scholar
  7. R. Soetikno, T. Kaltenbach, R. Yeh, and T. Gotoda, “Endoscopic mucosal resection for early cancers of the upper gastrointestinal tract,” Journal of Clinical Oncology, vol. 23, no. 20, pp. 4490–4498, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Hotta, T. Oyama, T. Akamatsu et al., “A comparison of outcomes of Endoscopic Submucosal Dissection (ESD) for early gastric neoplasms between high-volume and low-volume centers: multi-center retrospective questionnaire study conducted by the Nagano ESD Study Group,” Internal Medicine, vol. 49, no. 4, pp. 253–259, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. Japanese Gastric Cancer Association, “Japanese classification of gastric carcinoma—2nd English edition,” Gastric Cancer, vol. 1, no. 1, pp. 10–24, 1998. View at Google Scholar
  10. H. Katai and T. Sano, “Early gastric cancer: concepts, diagnosis, and management,” International Journal of Clinical Oncology, vol. 10, no. 6, pp. 375–383, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. “The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002,” Gastrointestinal Endoscopy, vol. 58, supplement 6, pp. S3–S43, 2003.
  12. R. J. Schlemper, M. Itabashi, Y. Kato et al., “Differences in diagnostic criteria for gastric carcinoma between Japanese and Western pathologists,” The Lancet, vol. 349, no. 9067, pp. 1725–1729, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. R. J. Schlemper, R. H. Riddell, Y. Kato et al., “The Vienna classification of gastrointestinal epithelial neoplasia,” Gut, vol. 47, no. 2, pp. 251–255, 2000. View at Google Scholar
  14. M. Kato, T. Nishida, S. Tsutsui et al., “Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia: a multicenter study by Osaka University ESD Study Group,” Journal of Gastroenterology, vol. 46, no. 3, pp. 325–331, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Miwa, H. Doyama, R. Ito et al., “Can magnifying endoscopy with narrow band imaging be useful for low grade adenomas in preoperative biopsy specimens?” Gastric Cancer, vol. 15, no. 2, pp. 170–178, 2012. View at Google Scholar
  16. K. Sugano, K. Sato, and K. Yao, “New diagnostic approaches for early detection of gastric cancer,” Digestive Diseases, vol. 22, no. 4, pp. 327–333, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Sano, Y. Okuyama, O. Kobori, T. Shimizu, and Y. Morioka, “Early gastric cancer: endoscopic diagnosis of depth of invasion,” Digestive Diseases and Sciences, vol. 35, no. 11, pp. 1340–1344, 1990. View at Google Scholar · View at Scopus
  18. S. Abe, I. Oda, T. Shimazu et al., “Depth-predicting score for differentiated early gastric cancer,” Gastric Cancer, vol. 14, no. 1, pp. 35–40, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Choi, S. G. Kim, J. P. Im, J. S. Kim, H. C. Jung, and I. S. Song, “Endoscopic prediction of tumor invasion depth in early gastric cancer,” Gastrointestinal Endoscopy, vol. 73, no. 5, pp. 917–927, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Toyoizumi, M. Kaise, H. Arakawa et al., “Ultrathin endoscopy versus high-resolution endoscopy for diagnosing superficial gastric neoplasia,” Gastrointestinal Endoscopy, vol. 70, no. 2, pp. 240–245, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Tajiri, A. Ohtsu, N. Boku et al., “Routine endoscopy using electronic endoscopes for gastric cancer diagnosis: retrospective study of inconsistencies between endoscopic and biopsy diagnoses,” Cancer Detection and Prevention, vol. 25, no. 2, pp. 166–173, 2001. View at Google Scholar · View at Scopus
  22. Y. Kawahara, R. Takenaka, H. Okada et al., “Novel chromoendoscopic method using an acetic acid-indigocarmine mixture for diagnostic accuracy in delineating the margin of early gastric cancers,” Digestive Endoscopy, vol. 21, no. 1, pp. 14–19, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Dinis-Ribeiro, “Chromoendoscopy for early diagnosis of gastric cancer,” European Journal of Gastroenterology & Hepatology, vol. 18, no. 8, pp. 831–838, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Yao, G. K. Anagnostopoulos, and K. Ragunath, “Magnifying endoscopy for diagnosing and delineating early gastric cancer,” Endoscopy, vol. 41, no. 5, pp. 462–467, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Ezoe, M. Muto, N. Uedo et al., “Magnifying narrowband imaging is more accurate than conventional white-light imaging in diagnosis of gastric mucosal cancer,” Gastroenterology, vol. 141, no. 6, pp. 2017.e3–2025.e3, 2011. View at Google Scholar
  26. T. Nagahama, K. Yao, S. Maki et al., “Usefulness of magnifying endoscopy with narrow-band imaging for determining the horizontal extent of early gastric cancer when there is an unclear margin by chromoendoscopy (with video),” Gastrointestinal Endoscopy, vol. 74, no. 6, pp. 1259–1267, 2011. View at Google Scholar
  27. S. Yoshinaga, T. Gotoda, and I. Oda, “Clinical imaging of early gastric cancers—conventional endoscopy: including chromoendoscopy using indigo carmine,” Stomach Intestine, vol. 44, pp. 650–662, 2009. View at Google Scholar
  28. S. Kiyotoki, J. Nishikawa, M. Satake et al., “Usefulness of magnifying endoscopy with narrow-band imaging for determining gastric tumor margin,” Journal of Gastroenterology and Hepatology, vol. 25, no. 10, pp. 1636–1641, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Yoshinaga, I. Oda, S. Nonaka, R. Kushima, and Y. Saito, “Endoscopic ultrasound using ultrasound probes for the diagnosis of early esophageal and gastric cancers,” World Journal of Gastrointestinal Endoscopy, vol. 4, no. 6, pp. 218–226, 2012. View at Google Scholar
  30. H. Yanai, Y. Matsumoto, T. Harada et al., “Endoscopic ultrasonography and endoscopy for staging depth of invasion in early gastric cancer: a pilot study,” Gastrointestinal Endoscopy, vol. 46, no. 3, pp. 212–216, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Akahoshi, Y. Chijilwa, S. Hamada et al., “Pretreatment staging of endoscopically early gastric cancer with a 15 MHz ultrasound catheter probe,” Gastrointestinal Endoscopy, vol. 48, no. 5, pp. 470–476, 1998. View at Google Scholar · View at Scopus
  32. G. H. Kim, D. Y. Park, M. Kida et al., “Accuracy of high-frequency catheter-based endoscopic ultrasonography according to the indications for endoscopic treatment of early gastric cancer,” Journal of Gastroenterology and Hepatology, vol. 25, no. 3, pp. 506–511, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Tsuzukr, H. Okada, Y. Kawahara et al., “Usefulness and problems of endoscopic ultrasonography in prediction of the depth of tumor invasion in early gastric cancer,” Acta Medica Okayama, vol. 65, no. 2, pp. 105–112, 2011. View at Google Scholar · View at Scopus
  34. D. Kikuchi, T. Iizuka, S. Hoteya et al., “Usefulness of endoscopic ultrasound for the prediction of intraoperative bleeding of endoscopic submucosal dissection for gastric neoplasms,” Journal of Gastroenterology and Hepatology, vol. 26, no. 1, pp. 68–72, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Sasako, T. Kinoshita, and K. Maruyama, “Prognosis of early gastric cancer,” Stomach Intestine, vol. 28, pp. 139–146, 1993. View at Google Scholar
  36. T. Sano, O. Kobori, and T. Muto, “Lymph node metastasis from early gastric cancer: endoscopic resection of tumour,” The British Journal of Surgery, vol. 79, no. 3, pp. 241–244, 1992. View at Google Scholar · View at Scopus
  37. M. Tada, M. Karita, H. Yanai, and T. Takemoto, “Endoscopic therapy of early gastric cancer by strip biopsy,” Japanese Journal of Cancer & Chemotherapy, vol. 15, no. 4, part 2-3, pp. 1460–1465, 1988. View at Google Scholar · View at Scopus
  38. S. Tsujitani, S. Oka, H. Saito et al., “Less invasive surgery for early gastric cancer based on the low probability of lymph node metastasis,” Surgery, vol. 125, no. 2, pp. 148–154, 1999. View at Publisher · View at Google Scholar · View at Scopus
  39. Japanese Gastric Cancer Association, Guidelines For the Treatment of Gastric Cancer, Kanehara, Tokyo, Japan, 2001.
  40. M. Matsushita, K. Hajiro, K. Okazaki, and H. Takakuwa, “Endoscopic mucosal resection of gastric tumors located in the lesser curvature of the upper third of the stomach,” Gastrointestinal Endoscopy, vol. 45, no. 6, pp. 512–515, 1997. View at Publisher · View at Google Scholar · View at Scopus
  41. H. Yamamoto, H. Kawata, K. Sunada et al., “Successful en-bloc resection of large superficial tumors in the stomach and colon using sodium hyaluronate and small-caliber-tip transparent hood,” Endoscopy, vol. 35, no. 8, pp. 690–694, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Oyama, A. Tomori, K. Hotta et al., “Endoscopic submucosal dissection of early esophageal cancer,” Clinical Gastroenterology and Hepatology, vol. 3, no. 7, supplement 1, pp. S67–S70, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. N. Yahagi, M. Fujishiro, N. Kakushima et al., “Endoscopic submucosal dissection for early gastric cancer using the tip of an electrosurgical snare (thin type),” Digestive Endoscopy, vol. 16, no. 1, pp. 34–38, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. C. Yokoi, T. Gotoda, H. Hamanaka, and I. Oda, “Endoscopic submucosal dissection allows curative resection of locally recurrent early gastric cancer after prior endoscopic mucosal resection,” Gastrointestinal Endoscopy, vol. 64, no. 2, pp. 212–218, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. T. Gotoda, A. Yanagisawa, M. Sasako et al., “Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers,” Gastric Cancer, vol. 3, no. 4, pp. 219–225, 2000. View at Google Scholar · View at Scopus
  46. T. Hirasawa, T. Gotoda, S. Miyata et al., “Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer,” Gastric Cancer, vol. 12, no. 3, pp. 148–152, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. I. Oda, T. Gotoda, H. Hamanaka et al., “Endoscopic submucosal dissection for early gastric cancer: technical feasibility, operation time and complications from a large consecutive series,” Digestive Endoscopy, vol. 17, no. 1, pp. 54–58, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. H. Isomoto, S. Shikuwa, N. Yamaguchi et al., “Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study,” Gut, vol. 58, no. 3, pp. 331–336, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. Y. M. Park, E. Cho, H. Y. Kang, and J. M. Kim, “The effectiveness and safety of endoscopic submucosal dissection compared with endoscopic mucosal resection for early gastric cancer: a systematic review and metaanalysis,” Surgical Endoscopy, vol. 25, no. 8, pp. 2666–2677, 2011. View at Google Scholar
  50. S. Nakamoto, Y. Sakai, J. Kasanuki et al., “Indications for the use of endoscopic mucosal resection for early gastric cancer in Japan: a comparative study with endoscopic submucosal dissection,” Endoscopy, vol. 41, no. 9, pp. 746–750, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. F. Catalano, A. Trecca, L. Rodella et al., “The modern treatment of early gastric cancer: our experience in an Italian cohort,” Surgical Endoscopy and Other Interventional Techniques, vol. 23, no. 7, pp. 1581–1586, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. M. O. Othman and M. B. Wallace, “Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in 2011, a Western perspective,” Clinics and Research in Hepatology and Gastroenterology, vol. 35, no. 4, pp. 288–294, 2011. View at Publisher · View at Google Scholar · View at Scopus
  53. N. Kakushima, N. Yahagi, M. Fujishiro et al., “The healing process of gastric artificial ulcers after endoscopic submucosal dissection,” Digestive Endoscopy, vol. 16, no. 4, pp. 327–331, 2004. View at Publisher · View at Google Scholar · View at Scopus
  54. N. Uedo, Y. Takeuchi, T. Yamada et al., “Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial,” The American Journal of Gastroenterology, vol. 102, no. 8, pp. 1610–1616, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. T. Kato, H. Araki, F. Onogi et al., “Clinical trial: rebamipide promotes gastric ulcer healing by proton pump inhibitor after endoscopic submucosal dissection-a randomized controlled study,” Journal of Gastroenterology, vol. 45, no. 3, pp. 285–290, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. T. Inaba, S. Ishikawa, T. Toyokawa et al., “Basal protrusion of ulcers induced by Endoscopic Submucosal Dissection (ESD) during treatment with proton pump inhibitors, and the suppressive effects of polaprezinc,” Hepato-Gastroenterology, vol. 57, no. 99-100, pp. 678–684, 2010. View at Google Scholar · View at Scopus
  57. N. Uedo, H. Iishi, M. Tatsuta et al., “Longterm outcomes after endoscopic mucosal resection for early gastric cancer,” Gastric Cancer, vol. 9, no. 2, pp. 88–92, 2006. View at Publisher · View at Google Scholar · View at Scopus
  58. T. Nakajima, I. Oda, T. Gotoda et al., “Metachronous gastric cancers after endoscopic resection: how effective is annual endoscopic surveillance?” Gastric Cancer, vol. 9, no. 2, pp. 93–98, 2006. View at Publisher · View at Google Scholar · View at Scopus
  59. T. Gotoda, M. Iwasaki, C. Kusano, S. Seewald, and I. Oda, “Endoscopie resection of early gastric cancer treated by guideline and expanded National Cancer Centre criteria,” The British Journal of Surgery, vol. 97, no. 6, pp. 868–871, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. H. H. Kim, W. J. Hyung, G. S. Cho et al., “Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report-a phase III multicenter, prospective, randomized trial (KLASS trial),” Annals of Surgery, vol. 251, no. 3, pp. 417–420, 2010. View at Publisher · View at Google Scholar · View at Scopus
  61. H. Ohtani, Y. Tamamori, K. Noguchi et al., “A meta-analysis of randomized controlled trials that compared laparoscopy-assisted and open distal gastrectomy for early gastric cancer,” Journal of Gastrointestinal Surgery, vol. 14, no. 6, pp. 958–964, 2010. View at Publisher · View at Google Scholar · View at Scopus
  62. X. Jiang, N. Hiki, H. Yoshiba et al., “Laparoscopy-assisted gastrectomy in patients with previous endoscopic resection for early gastric cancer,” The British Journal of Surgery, vol. 98, no. 3, pp. 385–390, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. H. Tonouchi, Y. Mohri, M. Kobayashi, K. Tanaka, M. Ohi, and M. Kusunoki, “Laparoscopy-assisted distal gastrectomy with laparoscopic sentinel lymph node biopsy after endoscopic mucosal resection for early gastric cancer,” Surgical Endoscopy and Other Interventional Techniques, vol. 21, no. 8, pp. 1289–1293, 2007. View at Publisher · View at Google Scholar · View at Scopus
  64. C. Kusano, M. Iwasaki, T. Kaltenbach, A. Conlin, I. Oda, and T. Gotoda, “Should elderly patients undergo additional surgery after non-curative endoscopic resection for early gastric cancer? long-term comparative outcomes,” The American Journal of Gastroenterology, vol. 106, no. 6, pp. 1064–1069, 2011. View at Publisher · View at Google Scholar · View at Scopus
  65. N. Abe, T. Mori, H. Takeuchi et al., “Laparoscopic lymph node dissection after endoscopic submucosal dissection: a novel and minimally invasive approach to treating early-stage gastric cancer,” American Journal of Surgery, vol. 190, no. 3, pp. 496–503, 2005. View at Publisher · View at Google Scholar · View at Scopus
  66. N. Abe, H. Takeuchi, A. Ohki et al., “Long-term outcomes of combination of endoscopic submucosal dissection and laparoscopic lymph node dissection without gastrectomy for early gastric cancer patients who have a potential risk of lymph node metastasis,” Gastrointestinal Endoscopy, vol. 74, no. 4, pp. 792–797, 2011. View at Google Scholar
  67. N. Hiki, Y. Yamamoto, T. Fukunaga et al., “Laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor dissection,” Surgical Endoscopy and Other Interventional Techniques, vol. 22, no. 7, pp. 1729–1735, 2008. View at Publisher · View at Google Scholar · View at Scopus
  68. S. Nunobe, N. Hiki, T. Gotoda et al., “Successful application of laparoscopic and endoscopic cooperative surgery (LECS) for a lateral-spreading mucosal gastric cancer,” Gastric Cancer, vol. 15, no. 3, pp. 338–342, 2012. View at Google Scholar
  69. H. Inoue, H. Ikeda, T. Hosoya et al., “Endoscopic mucosal resection, endoscopic submucosal dissection, and beyond: full-layer resection for gastric cancer with nonexposure technique (CLEAN-NET),” Surgical Oncology Clinics of North America, vol. 21, no. 1, pp. 129–140, 2012. View at Google Scholar
  70. O. Goto, T. Mitsui, M. Fujishiro et al., “New method of endoscopic full-thickness resection: a pilot study of non-exposed endoscopic wall-inversion surgery in an ex vivo porcine model,” Gastric Cancer, vol. 14, no. 2, pp. 183–187, 2011. View at Publisher · View at Google Scholar · View at Scopus