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Diagnostic and Therapeutic Endoscopy
Volume 2013 (2013), Article ID 327036, 6 pages
Clinical Study

Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis in Pancreatic Cancer: A Prospective Pilot Study of Safety Using 10 mL versus 20 mL Alcohol

1Division of Gastroenterology and Hepatology, Indiana University Medical Center, 550 North University Boulevard, UH 4100, Indianapolis, IN 46202, USA
2Department of Adult Health, School of Nursing, Indiana University, Indianapolis, IN 46202, USA
3Department of Biostatistics, School of Medicine, Indiana University, 410 W. Tenth Sreet, Suite 3000, Indianapolis, IN 46202-3012, USA
4School of Medicine, Indiana University, Indianapolis, IN 46202-3082, USA
5Regenstrief Institute, Indianapolis, IN, USA
6Houston VA Health Services Research & Development Center of Excellence, Indianapolis, IN, USA

Received 8 November 2012; Revised 7 December 2012; Accepted 7 December 2012

Academic Editor: Charles Melbern Wilcox

Copyright © 2013 Julia K. LeBlanc et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The dose of alcohol used in EUS-CPN is not standardized. The objective was to compare the safety of 20 mL alcohol versus 10 mL alcohol during EUS-CPN for patients with pancreatic cancer-related pain. Methods. 20 patients were selected to receive 10 mL or 20 mL of alcohol during EUS-CPN. Followup was done at baseline, 24 hours, and weekly. Health-related quality of life (HRQoL) was assessed at baseline, week 2, week 4, and every 4 weeks thereafter until pain returned. Results. There were no major complications in both groups. Minor self-limited adverse effects were seen in 6 (30%) subjects and included lightheadedness in 1 (5%), transient diarrhea in 2 (10%), and transient nausea and vomiting in 3. Pain relief was similar in both groups: 80% in the 10 mL group and 100% in the 20 mL group ( ). The mean (± SD) duration of pain relief in the 10 mL and 20 mL groups was and weeks, respectively. 30% of patients in each group had complete pain relief. Conclusions. EUS-CPN using 20 mL of alcohol is safe. Similar clinical outcomes were seen in both groups. Further investigations to confirm these findings are warranted.