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Evidence-Based Complementary and Alternative Medicine
Volume 1, Issue 1, Pages 93-98
http://dx.doi.org/10.1093/ecam/neh009
Original Article

Ozone Therapy for Tumor Oxygenation: a Pilot Study

1Radiation Oncology and Research Unit, Las Palmas (Canary Islands), Spain
2Medical Physics, Las Palmas (Canary Islands), Spain
3La Paterna Medical Center, Las Palmas (Canary Islands), Spain
4Chronic Pain Unit, Dr Negrín Hospital, Las Palmas (Canary Islands), Spain
5Canary Islands Institute for Cancer Research (ICIC), Las Palmas (Canary Islands), Spain

Received 17 November 2003; Accepted 4 February 2004

Copyright © 2004 Bernardino Clavo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [16 citations]

The following is the list of published articles that have cited the current article.

  • Bernardino Clavo, Ana Ruiz, Marta Lloret, Laura Lopez, Gerardo Suarez, David Macias, Victor Rodriguez, Maria A. Hernandez, Roberto Martin-Oliva, Santiago Quintero, Jose M. Cuyas, and Francisco Robaina, “Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study,” Evidence-Based Complementary and Alternative Medicine, vol. 1, no. 3, pp. 321–325, 2004. View at Publisher · View at Google Scholar
  • Bernardino Clavo, Luis Catala, Juan L. Perez, Victor Rodriguez, and Francisco Robaina, “Ozone Therapy on Cerebral Blood Flow: A Preliminary Report,” Evidence-Based Complementary and Alternative Medicine, vol. 1, no. 3, pp. 315–319, 2004. View at Publisher · View at Google Scholar
  • Velio Bocci, Alessandra Larini, and Vanna Micheli, “Restoration of Normoxia by Ozone Therapy May Control Neoplastic Growth: A Review and a Working Hypothesis,” The Journal of Alternative and Complementary Medicine, vol. 11, no. 2, pp. 257–265, 2005. View at Publisher · View at Google Scholar
  • A. Cannizzaro, C. Verga Falzacappa, M. Martinelli, S. Misiti, E. Brunetti, and B. Bucci, “O2/3 exposure inhibits cell progression affecting cyclin B1/cdk1 activity in SK-N-SH while induces apoptosis in SK-N-DZ neuroblastoma cells,” Journal of Cellular Physiology, vol. 213, no. 1, pp. 115–125, 2007. View at Publisher · View at Google Scholar
  • Silvia Menéndez, Janet Cepero, and Luis Borrego, “Ozone Therapy in Cancer Treatment: State of the Art,” Ozone: Science & Engineering, vol. 30, no. 6, pp. 398–404, 2008. View at Publisher · View at Google Scholar
  • Velio Bocci, and Velio Bocci, “The Clinical Application of Ozonetherapy,” Ozone, pp. 97–232, 2010. View at Publisher · View at Google Scholar
  • Saad Zaky, Ehab Ahmad Fouad, and Hassan Ibrahim Mohamad Kotb, “The effect of rectal ozone on the portal vein oxygenation and pharmacokinetics of propranolol in liver cirrhosis (a preliminary human study),” British Journal of Clinical Pharmacology, vol. 71, no. 3, pp. 411–415, 2011. View at Publisher · View at Google Scholar
  • Nancy Scanlan, and Nancy Scanlan, “Other Commonly Employed Modalities,” Complementary Medicine for Veterinary Technicians and Nurses, pp. 217–249, 2013. View at Publisher · View at Google Scholar
  • Arizbeth Pérez, Clara L. Santos Cuevas, Isaac Chairez, Tatyana Poznyak, David Ordaz-Rosado, Rocío García-Becerra, and Mario E. Romero Piña, “Ozone dosage effect on C6 cell growth, in vitro and in vivo tests: double bond index for characterization,” Analytical Methods, vol. 6, no. 13, pp. 4567, 2014. View at Publisher · View at Google Scholar
  • Tomohiro Osaki, Norihiko Ito, Tomohiro Imagawa, Fumio Itoh, Yoshiharu Okamoto, Kohei Kuroda, Kazuo Azuma, Takuro Mori, Kinya Kawamoto, Yusuke Murahata, and Takeshi Tsuka, “The Safety and Anti-Tumor Effects of Ozonated Water in Vivo,” International Journal Of Molecular Sciences, vol. 16, no. 10, pp. 25108–25120, 2015. View at Publisher · View at Google Scholar
  • Arizbeth Perez, Clara L. Santos Cuevas, Isaac Chairez, Tatyana Poznyak, David Ordaz-Rosado, Rocio Garcia-Becerra, and Mario E. Romero Pina, “Ozone dosage effect on C6 Cell Growth: In vitro and in vivo Tests,” Anti-Cancer Agents In Medicinal Chemistry, vol. 15, no. 9, pp. 1190–1196, 2015. View at Publisher · View at Google Scholar
  • Filippo Molinari, Daniele Rimini, William Liboni, U. Rajendra Acharya, Marianno Franzini, Sergio Pandolfi, Giovanni Ricevuti, Francesco Vaiano, Luigi Valdenassi, and Vincenzo Simonetti, “Cerebrovascular pattern improved by ozone autohemotherapy: an entropy-based study on multiple sclerosis patients,” Medical & Biological Engineering & Computing, 2016. View at Publisher · View at Google Scholar
  • Kiziltan Hs, “Successfull Pain Management with Radiotherapy and Ozone Therapy in a Case of Metastatic, Chemotherapy Resistant Sino-Nasal Mucosal Malignant Melanoma,” MOJ Clinical & Medical Case Reports, vol. 6, no. 4, 2017. View at Publisher · View at Google Scholar
  • V. Simonetti, V. Quagliariello, P. Giustetto, M. Franzini, and R. V. Iaffaioli, “Association of Ozone with 5-Fluorouracil and Cisplatin in Regulation of Human Colon Cancer Cell Viability: In Vitro Anti-Inflammatory Properties of Ozone in Colon Cancer Cells Exposed to Lipopolysaccharides,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, pp. 1–6, 2017. View at Publisher · View at Google Scholar
  • Bernardino Clavo, Norberto Santana-Rodríguez, Pedro Llontop, Dominga Gutiérrez, Gerardo Suárez, Laura López, Gloria Rovira, Gregorio Martínez-Sánchez, Esteban González, Ignacio J. Jorge, Carmen Perera, Jesús Blanco, and Francisco Rodríguez-Esparragón, “Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted?,” Evidence-Based Complementary and Alternative Medicine, vol. 2018, pp. 1–11, 2018. View at Publisher · View at Google Scholar
  • Jesse A. Stoff, “Selected Office Based Anticancer Treatment Strategies,” Journal of Oncology, vol. 2019, pp. 1–14, 2019. View at Publisher · View at Google Scholar