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Evidence-Based Complementary and Alternative Medicine
Volume 3 (2006), Issue 2, Pages 249-254
Original Article

Bioactive Constituents of Brazilian Red Propolis

1Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
2Faculdade de Farmacia, Universidade Bandeirante de Sao Paulo Rua Maria Candida, 1813, Vila Guilherme, Campus MC, 02071-013 Sao Paulo, SP, Brazil
3Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Building 26, 1113 Sofia, Bulgaria

Received 10 November 2005; Accepted 10 February 2006

Copyright © 2006 Boryana Trusheva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In a new propolis type, red Brazilian propolis, 14 compounds were identified (six of them new for propolis), among them simple phenolics, triterepenoids, isoflavonoids, prenylated benzophenones and a naphthoquinone epoxide (isolated for the first time from a natural source). Three of the major components demonstrated significant antimicrobial activity, and two (obtained as inseparable mixture) possessed radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH).