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Evidence-Based Complementary and Alternative Medicine
Volume 4 (2007), Issue 4, Pages 419-423
http://dx.doi.org/10.1093/ecam/nel094
Original Article

Immunomodulatory Activity of Chlorophytum borivilianum Sant. F

Department of Pharmaceutical Sciences, Dr H.S. Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India

Received 21 May 2006; Accepted 13 October 2006

Copyright © 2007 Mayank Thakur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chlorophytum borivilianum Santapau & Fernandes (Liliaceae) is a very popular herb in traditional Indian medicine and constitute a group of herbs used as ‘Rasayan’ or adaptogen. Ethanolic extract of the roots and its sapogenin were evaluated for their immunomodulatory activity. Effect of azathioprine-induced myelosuppresion and administration of extracts on hematological and serological parameters was determined. Administration of extracts greatly improved survival against Candida albicans infection. An increase in delayed-type hypersensitivity response (DTH), % neutrophil adhesion and in vivo phagocytosis by carbon clearance method was observed after treatment with extracts. Immunostimulant activity of ethanolic extract was more pronounced as compared to sapogenins. The results, thus justifies the traditional use of C. borivilianum as a rasayana drug.