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Evidence-Based Complementary and Alternative Medicine
Volume 4, Issue 3, Pages 351-353
http://dx.doi.org/10.1093/ecam/nel099
Original Article

In Vitro Anti-Candida Activity of Zataria multiflora Boiss

1Department of Medical Mycoparasitology, School of Medicine, Jundishapour University of Medical Sciences Ahwaz, Iran
2School of Pharmacy, Jundishapour University of Medical Sciences Ahwaz, Iran
3School of Nursing and Midwifery, Jundishapour University of Medical Sciences Ahwaz, Iran

Received 15 May 2006; Accepted 30 October 2006

Copyright © 2007 Ali Zarei Mahmoudabadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Zataria multiflora Boiss known as Avishan Shirazi (in Iran) is one of the valuable Iranian medicinal plants. The aim of study was to evaluate anti-Candida activity of Z. multiflora against different species of Candida in vitro. Anti-Candida activity of the aqueous, ethanolic and methanolic maceration extract of the aerial parts of Z. multiflora Boiss was studied in vitro. Anti-Candida activity against Candida species was done using serial dilutions of extracts in Sabouraud's dextrose agar. Minimal inhibitory concentration (MIC) of the methanolic and ethanolic extracts was 70.7 and 127 mg l−1, respectively. Aqueous extract showed no remarkable activity against Candida species. We conclude that methanolic extract of the aerial parts of Z. multiflora Boiss has more anti-Candida effect at 70.7 mg l−1 compared to ethanolic extract 127 mg l−1. In addition, the isolates of Candida parapsilosis were more susceptible to methanolic extract than other tested species.