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Evidence-Based Complementary and Alternative Medicine
Volume 4 (2007), Issue 2, Pages 247-250
Original Article

Three Case Reports to Illustrate Clinical Applications in the Use of Erythrocyte Transketolase

24700 Center Ridge Road, Westlake, OH 44145, USA

Received 4 March 2006; Accepted 12 October 2006

Copyright © 2007 Derrick Lonsdale. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Non-caloric nutrients (NCN) are extremely numerous and it is more than obvious that they work in a team relationship. These vitally important interactions are, for the most part, poorly understood. These brief case reports illustrate this in the therapeutic use of thiamin in a clinical setting. The initially abnormal erythrocyte transketolase activity (TKA) and/or the thiamin pyrophosphate effect (TPPE), indicating intracellular cofactor deficiency, usually improves with thiamin administration. Biochemical correction of the abnormality is, however, invariably dependent on the provision of other NCN, especially magnesium. In two patients reported here, this correction required several infusions containing magnesium and other NCN administered intravenously. In a third patient, hemoconcentration associated with an abnormal TPPE was normalized after administration of nutrients that included thiamin and magnesium.