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Evidence-Based Complementary and Alternative Medicine
Volume 6 (2009), Issue 4, Pages 517-522
http://dx.doi.org/10.1093/ecam/nem156
Original Article

Antiviral Activity of Some Plants Used in Nepalese Traditional Medicine

1Research Center for Applied Science and Technology, Tribhuvan University, Kathmandu, Nepal
2Friedrich-Loeffler-Institute of Medical Microbiology, Ernst-Moritz-Arndt-University Greifswald, Martin-Luther-Strasse 6, 17487 Greifswald, Germany
3Central Department of Botany, Tribhuvan University, Kathmandu, Nepal
4Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Ludwig-Jahn-Strasse 17, 17487 Greifswald, Germany

Received 23 April 2007; Accepted 21 September 2007

Copyright © 2009 M. Rajbhandari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Methanolic extracts of 41 plant species belonging to 27 families used in the traditional medicine in Nepal have been investigated for in vitro antiviral activity against Herpes simplex virus type 1 (HSV-1) and influenza virus A by dye uptake assay in the systems HSV-1/Vero cells and influenza virus A/MDCK cells. The extracts of Astilbe rivularis, Bergenia ciliata, Cassiope fastigiata and Thymus linearis showed potent anti-herpes viral activity. The extracts of Allium oreoprasum, Androsace strigilosa, Asparagus filicinus, Astilbe rivularis, Bergenia ciliata and Verbascum thapsus exhibited strong anti-influenza viral activity. Only the extracts of A. rivularis and B. ciliata demonstrated remarkable activity against both viruses.