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Evidence-Based Complementary and Alternative Medicine
Volume 6, Issue 3, Pages 317-324
http://dx.doi.org/10.1093/ecam/nem119
Original Article

Ficus racemosa Stem Bark Extract: A Potent Antioxidant and a Probable Natural Radioprotector

1Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal-576 104, Karnataka, India
2Radiobiology, Kasturba Medical College, Manipal-576 104, Karnataka, India
3Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal-576 104, Karnataka, India
4Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Mumbai-400085, India

Received 17 November 2006; Accepted 19 July 2007

Copyright © 2009 V. P. Veerapur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [44 citations]

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  • Olayinka A. Aiyegoro, and Anthony I. Okoh, “Preliminary phytochemical screening and In vitro antioxidant activities of the aqueous extract of Helichrysum longifolium DC,” Bmc Complementary And Alternative Medicine, vol. 10, 2010. View at Publisher · View at Google Scholar
  • Jing Xie, Yan-Tao Han, Chun-Bo Wang, and Wen-Gong Yu, “ Purple sweet potato pigments protect murine thymocytes from 60 Co γ-ray-induced mitochondria-mediated apoptosis ,” International Journal of Radiation Biology, vol. 86, no. 12, pp. 1061–1069, 2010. View at Publisher · View at Google Scholar
  • Bhakta P. Gaire, Ramakanta Lamichhane, Chitra B. Sunar, Amrita Shilpakar, Sabita Neupane, and Sushil Panta, “Phytochemical screening and analysis of antibacterial and antioxidant activity of Ficus auriculata (Lour.) stem bark,” Pharmacognosy Journal, vol. 3, no. 21, pp. 49–55, 2011. View at Publisher · View at Google Scholar
  • Aiyalu Rajasekaran, and Muthusamy Kalaivani, “Hypolipidemic and antioxidant activity of aqueous extract of Monascus purpureus fermented Indian rice in high cholesterol diet fed rats,” Turkish Journal Of Medical Sciences, vol. 41, no. 1, pp. 25–32, 2011. View at Publisher · View at Google Scholar
  • Olayinka A. Aiyegoro, and Sandra van Dyk, “The antioxidant properties, cytotoxicity and monoamine oxidase inhibition abilities of the crude dichloromethane extract of Tarchonanthus camphoratus L. leaves,” African Journal Of Biotechnology, vol. 10, no. 75, pp. 17297–17304, 2011. View at Publisher · View at Google Scholar
  • Olubunmi Abosede Wintola, and Anthony Jide Afolayan, “Phytochemical constituents and antioxidant activities of the whole leaf extract of Aloe ferox Mill.,” Pharmacognosy Magazine, vol. 7, no. 28, pp. 325–333, 2011. View at Publisher · View at Google Scholar
  • Yin-Xian Shi, You-Kai Xu, Hua-Bin Hu, Zhi Na, and Wen-Hui Wang, “Preliminary assessment of antioxidant activity of young edible leaves of seven Ficus species in the ethnic diet in Xishuangbanna, Southwest China,” Food Chemistry, vol. 128, no. 4, pp. 889–894, 2011. View at Publisher · View at Google Scholar
  • Pankaj Chaudhary, Sandeep Kumar Shukla, and Rakesh Kumar Sharma, “REC-2006—A Fractionated Extract of Podophyllum hexandrum Protects Cellular DNA from Radiation-Induced Damage by Reducing the Initial Damage and Enhancing Its Repair In Vivo,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, pp. 1–9, 2011. View at Publisher · View at Google Scholar
  • Kun-Teng Wang, Lih-Geeng Chen, Duen-Suey Chou, Wen-Li Liang, and Ching-Chiung Wang, “Anti-Oxidative Abilities of Essential Oils from Atractylodes ovata Rhizome,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, pp. 1–9, 2011. View at Publisher · View at Google Scholar
  • Sandeep Rawat, Arun Jugran, Lalit Giri, Indra D. Bhatt, and Ranbeer S. Rawal, “Assessment of Antioxidant Properties in Fruits of Myrica esculenta: A Popular Wild Edible Species in Indian Himalayan Region,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, pp. 1–8, 2011. View at Publisher · View at Google Scholar
  • Sandra M. Barbalho, Débora C. Damasceno, Ana Paula Machado Spada, Vanessa Sellis da Silva, Karla Aparecida Martuchi, Marie Oshiiwa, Flávia M. V. Farinazzi Machado, and Claudemir Gregório Mendes, “Metabolic Profile of Offspring from Diabetic Wistar Rats Treated with Mentha piperita (Peppermint),” Evidence-Based Complementary and Alternative Medicine, vol. 2011, pp. 1–6, 2011. View at Publisher · View at Google Scholar
  • Reelma Velho-Pereira, A. Kumar, B.N. Pandey, K.P. Mishra, and Aarti G. Jagtap, “Radioprotection by macerated extract of Nigella sativa in normal tissues of fibrosarcoma bearing mice,” Indian Journal of Pharmaceutical Sciences, vol. 74, no. 5, pp. 403–414, 2012. View at Publisher · View at Google Scholar
  • Duraisamy Gomathi, Ganesan Ravikumar, Manokaran Kalaiselvi, Balasubramaniam Vidya, and Chandrasekar Uma, “HPTLC fingerprinting analysis of Evolvulus alsinoides (L.) L.,” Journal of Acute Medicine, vol. 2, no. 3, pp. 77–82, 2012. View at Publisher · View at Google Scholar
  • Arul-Albert Baskar, Khalid-S. Al. Numair, Mohammed-A. Alsaif, and Savarimuthu Ignacimuthu, “In vitro antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer,” Redox Report, vol. 17, no. 4, pp. 145–156, 2012. View at Publisher · View at Google Scholar
  • P. Habbu, D. M. Smita, K. M. Mahadevan, R. A. Shastry, and S. M. Biradar, “Protective effect of Habenaria intermedia tubers against acute and chronic physical and psychological stress paradigs in rats,” Revista Brasileira De Farmacognosia-Brazilian Journal Of Pharmacognosy, vol. 22, no. 3, pp. 568–579, 2012. View at Publisher · View at Google Scholar
  • V.P. Veerapur, K.R. Prabhakar, B.S. Thippeswamy, Punit Bansal, K.K. Srinivasan, and M.K. Unnikrishnan, “Antidiabetic effect of Ficus racemosa Linn. stem bark in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats: A mechanistic study,” Food Chemistry, vol. 132, no. 1, pp. 186–193, 2012. View at Publisher · View at Google Scholar
  • Indra D. Bhatt, Sandeep Rawat, and Ranbeer S. Rawalpp. 295–326, 2012. View at Publisher · View at Google Scholar
  • Punit Bansal, Piya Paul, Amit Kunwar, S. Jayakumar, Pawan G. Nayak, K.I. Priyadarsini, and M.K. Unnikrishnan, “Radioprotection by quercetin-3-O-rutinoside, a flavonoid glycoside – A cellular and mechanistic approach,” Journal of Functional Foods, vol. 4, no. 4, pp. 924–932, 2012. View at Publisher · View at Google Scholar
  • Periyar Rangasamy Rathi Sre, Toda Sheila, and Kandasamy Murugesan, “Phytochemical screening and “in–vitro” anti–oxidant activity of methanolic root extract of Erythrina indica,” Asian Pacific Journal of Tropical Biomedicine, vol. 2, no. 3, pp. S1696–S1700, 2012. View at Publisher · View at Google Scholar
  • Limpp. 1–159, 2012. View at Publisher · View at Google Scholar
  • Piya Paul, Punit Bansal, Pawan G. Nayak, Steve Thomas Pannakal, K.I. Priyadarsini, and M.K. Unnikrishnan, “Polyphenolic fraction of Pilea microphylla (L.) protects Chinese hamster lung fibroblasts against γ-radiation-induced cytotoxicity and genotoxicity,” Environmental Toxicology and Pharmacology, vol. 33, no. 1, pp. 107–119, 2012. View at Publisher · View at Google Scholar
  • Lin-Lin Gao, Fu-Rong Li, Shu-Tong Yao, and Shu-Cun Qin, “The anti-oxidative and anti-inflammatory effects of dioscin from the roots of Paris Polyphylla Smith,” Proceedings of 2012 International Symposium on Information Technologies in Medicine and Education, ITME 2012, vol. 2, pp. 786–789, 2012. View at Publisher · View at Google Scholar
  • Hyo Jung Kim, Ji-Yeon Seo, Hwa-Jin Suh, Soon Sung Lim, and Jong-Sang Kim, “Antioxidant activities of licorice-derived prenylflavonoids,” Nutrition Research and Practice, vol. 6, no. 6, pp. 491, 2012. View at Publisher · View at Google Scholar
  • Tarika Thumvijit, Waristha Thuschana, Doungporn Amornlerdpison, Yuwadee Peerapornpisal, and Rawiwan Wongpoomchai, “Evaluation of hepatic antioxidant capacities of Spirogyra neglecta (Hassall) Kützing in rats,” Interdisciplinary Toxicology, vol. 6, no. 3, pp. 152–156, 2013. View at Publisher · View at Google Scholar
  • S.S. Nipate, V.P. Londhe, and A.H. Tiwari, “Effect of Transdermal Patch of Ficus racemosa Leaves Extract on Dermal Burn Wound,” Pharmacologia, vol. 4, no. 5, pp. 365–370, 2013. View at Publisher · View at Google Scholar
  • Pawan G. Nayak, Piya Paul, Punit Bansal, Nampurath Gopalan Kutty, and Karkala Sreedhara Ranganath Pai, “Sesamol prevents doxorubicin-induced oxidative damage and toxicity on H9c2 cardiomyoblasts,” Journal of Pharmacy and Pharmacology, 2013. View at Publisher · View at Google Scholar
  • Sandip Pal, Chabita Saha, and Subrata Kumar Dey, “Studies on black tea (Camellia sinensis) extract as a potential antioxidant and a probable radioprotector,” Radiation and Environmental Biophysics, vol. 52, no. 2, pp. 269–278, 2013. View at Publisher · View at Google Scholar
  • Thanyawan Pluemsamran, Pinpat Tripatara, Rattana Phadungrakwittaya, Pravit Akarasereenont, Tawee Laohapand, and Uraiwan Panich, “Redox Mechanisms of AVS022, an Oriental Polyherbal Formula, and Its Component Herbs in Protection against Induction of Matrix Metalloproteinase-1 in UVA-Irradiated Keratinocyte HaCaT Cells,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–10, 2013. View at Publisher · View at Google Scholar
  • Duraisamy Gomathi, Ganesan Ravikumar, Manokaran Kalaiselvi, Balasubramaniam Vidya, and Chandrasekar Uma, “In vitro free radical scavenging activity of ethanolic extract of the whole plant of Evolvulus Alsinoides (L.) L.,” Chinese Journal of Integrative Medicine, 2014. View at Publisher · View at Google Scholar
  • Sonia Sharma, and Adarsh Pal Vig, “Preliminary Phytochemical Screening and In Vitro Antioxidant Activities of Parkinsonia aculeata Linn.,” BioMed Research International, vol. 2014, pp. 1–8, 2014. View at Publisher · View at Google Scholar
  • Nazim Uddin, Nazim Uddin Ahmed, Atiar Rahman, Rasheda Akter, and Rehana Akter, “ Antioxidative Potential of the Polyphenolics of Stephania japonica var. Discolor (Blume) Forman: A Chromatographic (HPLC) and Spectrophotometric Measure ,” International Journal of Food Properties, pp. 150706132240005, 2015. View at Publisher · View at Google Scholar
  • Sakina Razack, Kandikattu Kumar, Ilaiyaraja Nallamuthu, Mahadeva Naika, and Farhath Khanum, “Antioxidant, Biomolecule Oxidation Protective Activities of Nardostachys jatamansi DC and Its Phytochemical Analysis by RP-HPLC and GC-MS,” Antioxidants, vol. 4, no. 1, pp. 185–203, 2015. View at Publisher · View at Google Scholar
  • S.S. Cengiz, D. Yesilbag, Y. Meral, I. Cetin, and H. Biricik, “Juniper oil improves oxidative stability and eggshell and albumin quality of quail eggs,” British Poultry Science, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Rajnish Kumar Yadav, Bankim Chandra Nandy, Siddhartha Maity, Srimanta Sarkar, and Sudipta Saha, “Phytochemistry, pharmacology, toxicology, and clinical trial of Ficus racemosa,” Pharmacognosy Reviews, vol. 9, no. 17, pp. 73–80, 2015. View at Publisher · View at Google Scholar
  • Linda I. Sowunmi, and Anthony J. Afolayan, “Phytochemical Constituents And Antioxidant Properties Of Acetone Extract Of Cleome Gynandra (L.) Growing In The Eastern Cape, South Africa.,” African Journal Of Traditional Complementary And Alternative Medicines, vol. 12, no. 3, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Arunika Subba, and Palash Mandal, “Pharmacognostic studies and in vitro antioxidant potential of traditional polyherbal formulation of west Sikkim with Asparagus Spp,” Pharmacognosy Journal, vol. 7, no. 6, pp. 348–355, 2015. View at Publisher · View at Google Scholar
  • Rafi Ullah, Jehan Bakht, and Mohammad Shafi, “Antimicrobial and anti-oxidant potential of Periploca hydaspidis,” Bangladesh Journal of Pharmacology, vol. 10, no. 3, pp. 645–651, 2015. View at Publisher · View at Google Scholar
  • Mozdarani, Mahmmoudzadeh, A. Shakeri Boroujeni, and Faeghi, “Potent radioprotective effect of herbal immunomodulator drug (IMOD) on mouse bone marrow erythrocytes as assayed with the micronucleus test,” Iranian Journal of Radiation Research, vol. 14, no. 3, pp. 221–228, 2016. View at Publisher · View at Google Scholar
  • Nidal Jaradat, and Murad Abualhasan, “Comparison of Phytoconstituents, Total Phenol Contents and Free Radical Scavenging Capacities between Four Arum Species from Jerusalem and Bethlehem,” Pharmaceutical Sciences, vol. 22, no. 2, pp. 120–125, 2016. View at Publisher · View at Google Scholar
  • Amith Kumar, Rajalakshmi Rai, Reshma Kumarchandra, and Satish Rao, “Radiomodulatory role of Psidium guajava leaf extracts against X-ray induced genotoxicity, oxidative stress and apoptosis in albino wistar rat model,” Journal of Applied Pharmaceutical Science, vol. 6, no. 3, pp. 58–65, 2016. View at Publisher · View at Google Scholar
  • Akuodor Godwin Christian, Megwas Anthony Uchenna, Ekenjoku John Azubuike, Nworie Emmanuel Michael, Grace Akanimo Essiet, and Aja Daniel Ogbonna, “Antidiarrhoeal and antioxidant properties of ethanol leaf extract of Pseudocedrela kotschyi,” Journal of Applied Pharmaceutical Science, vol. 6, no. 3, pp. 107–110, 2016. View at Publisher · View at Google Scholar
  • Manpreet Kaur Bagga, Ranu Gadi, and Gurmeet Singh, “ Ficus racemosa as corrosion inhibitor for mild steel in acid medium ,” Emerging Materials Research, vol. 6, no. 1, pp. 117–123, 2017. View at Publisher · View at Google Scholar
  • Raj Kumar Tiwari, Udayabanu, and Silpi Chanda, “Evaluation of in vitro antioxidant potential of aqueous root extract of Clerodendrum serratum L.,” Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 4, pp. 402–404, 2017. View at Publisher · View at Google Scholar
  • Xin He, Wei Long, Hui Dong, Chunhua Wang, Xiaofei Chu, Qisheng Zheng, and Saijun Fan, “Evaluation of the protective effects of 13 traditional Chinese medicine compounds on ionizing radiation injury: bupleurum, shenmai, and breviscapine as candidate radioprotectors,” RSC Adv., vol. 7, no. 37, pp. 22640–22648, 2017. View at Publisher · View at Google Scholar