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Evidence-Based Complementary and Alternative Medicine
Volume 6, S1, Pages 81-86
Original Article

Taeyeumjoweetang Affects Body Weight and Obesity-Related Genes in Mice

1Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
2Department of Rehabilitation, College of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Republic of Korea
3Department of Classics, College of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Republic of Korea
4Department of Physiology, College of Oriental Medicine, Wonkwang University, 344-2 Shinyoung-dong, Iksan, Chonbuk 570-749, Republic of Korea

Received 16 March 2009; Accepted 9 July 2009

Copyright © 2009 Si-Woo Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Taeyeumjoweetang (TYJWT) is a herbal medication that was mentioned in Jema Lee's Donguisusebowon, which is a book about Sasang constitutional medicine. Tae-eumnis, one of the four constitutions, tend to suffer from metabolic diseases such as obesity and diabetes. It is widely used to treat the digestive problems and obesity of Tae-eumins. We divided mice that were fed a normal diet for 48 days into control, TYJWT 250 mg kg-1 and TYJWT 500 mg kg-1 groups. After carrying out the experiments, the serum levels of leptin, adiponectin, ghrelin and resistin were measured. The results showed that TYJWT significantly reduced the weights of mice that were fed a normal diet, and that this was due to a decrease in food intake. Also, the two TYJWT groups had lower serum levels of leptin compared to the control group, and the ghrelin levels were proportionately increased by the dosage of TYJWT given. These results show that TYJWT has obesity-suppressing effects similar to those previously reported using high fat diets. In addition, these results also provide evidence that TYJWT has anti-obesity effects.