Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types

Table 1

Anthropometric and clinical characteristics of the subjects^a.

Feature	All	TE	SY	SE	𝑃-value*
Kirin population
Number (n)	835	685	81	69	—
Female (%)	93.4	92.1	98.8	100	—
Age (years)	27.7 ± 8.09	27.7 ± 8.01	28.8 ± 9.54	27.0 ± 6.93	.39
BMI (kg/m^2)	26.5 ± 4.66	27.2 ± 4.63	23.6 ± 3.48	23.0 ± 3.19	8.1 × 10^-20
WHR	0.888 ± 0.0755	0.897 ± 0.0759	0.849 ± 0.0578	0.840 ± 0.0549	2.4 × 10^-14
BMI loss (%)^a	−7.86 ± 4.10 (538)	−8.12 ± 3.98 (443)	−5.74 ± 4.55 (48)	−7.55 ± 4.16 (47)	5.4 × 10^-4
WHR loss (%)^a	−3.12 ± 2.52 (538)	−3.32 ± 2.45 (443)	−1.87 ± 2.46 (48)	−2.54 ± 2.82 (47)	1.7 × 10^-4
Multicenter population
Number (n)	535	196	172	137	—
Female (%)	64.2	57.1	70.9	66.9	—
Age (years)	42.6 ± 13.1	43.7 ± 13.9	43.0 ± 12.1	41.1 ± 12.9	.18
BMI (kg/m^2)	22.9 ± 3.09	25.0 ± 2.95	22.4 ± 2.54	20.9 ± 2.01	2.8 × 10^-30
WHR	0.885 ± 0.0736	0.915 ± 0.0632	0.876 ± 0.0671	0.858 ± 0.0806	5.0 × 10^-11

The values are given as mean ± SD; ^aThe percentage of a loss in body mass was calculated as one-hundredth of the value of body mass change after the weight-control program divided by the value before the program. The number of subjects participated in the program are indicated in parentheses; *The 𝑃-value (𝑃<.05, boldface) was calculated with analysis of variance.