Ethanol Extract of the Flower Chrysanthemum morifolium Augments Pentobarbital-Induced Sleep Behaviors: Involvement of Cl⁻ Channel Activation

Figure 5

A proposed mechanism of EFC in augmenting pentobarbital-induced sleep. EFC administration will increase expression levels of GAD, the rate-limiting enzyme in GABA biosynthesis, thereby increasing GABA levels. This will promote Cl⁻ channel opening, causing hyperpolarization of the post-synaptic neuron. Hyperpolarization may result in potentiation of pentobarbital-induced sleep.