Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects

Table 1

Influence of several drugs on T. catigua hydroalcoholic extract antinociception effect expressed as MPE (%).

Treatment (dose)	Antagonist (dose)	Site/mechanism of action	MPE (%)
Morphine (5 mg kg^−1, s.c.)	PBS	—	100
	Naloxone (2.5 mg kg^−1, i.p.)	Non-specific opioid receptor antagonist	0
T. catigua (200 mg kg^−1, p.o.)	PBS	—	39  ±  10
	Prazosin (1 mg kg^−1, i.p.)	𝛼1-adrenergic receptor antagonist,	38  ±  8
	SR141716A (10 mg kg^−1, i.p.)	Cannabinoid receptor antagonist	45  ±  7
	SCH23390 (15 𝜇g kg^−1, i.p.)	D1 receptor antagonist	0
	Sulpiride (50 mg kg^−1, i.p.)	D2 receptor antagonist	48  ±  12
	Bicuculline (1 mg kg^−1, i.p.)	GABAA receptor antagonist	22  ±  10
	Naloxone (2.5 mg kg^−1, i.p.)	Non-specific opioid receptor antagonist	20  ±  13
	PCPA (100 mg kg^−1, i.p.)	Serotonin synthesis inhibitor	48  ±  8

Each group represents the mean  ±  SEM of 10 animals.