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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 128349, 5 pages
Original Article

Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity

1Unesp, Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, Rodovia Araraquara-Jaú km 01, CEP 14801-902, Araraquara–SP, Brazil
2Unesp, Universidade Estadual Paulista, Instituto de Química, Rua Francisco Degni s/n. Bairro Quitandinha, C.P.335. CEP 14800-900, Araraquara–SP, Brazil
3Instituto Adolfo Lutz, Laboratório de Micobacteriologia, Rua Minas, 887, CEP 14085-410, Ribeirão Preto, SP, Brazil
4Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, USA

Received 28 June 2008; Accepted 14 November 2008

Copyright © 2011 C. T. Higuchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration—MIC, 62.5 μg mL−1), triterpenoids as bassic acid (MIC = 2.5 μg mL−1), α-amyrin acetate (MIC = 62.5 μg mL−1), a mixture of lupeol, α- and β-amyrin (MIC = 31.5 μg mL−1) and a mixture of lupeol, and acetates of α- and β-amyrin (MIC = 31.5 μg mL−1). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).