Biphasic Effect of Phyllanthus emblica L. Extract on NSAID-Induced
Ulcer: An Antioxidative Trail Weaved with Immunomodulatory Effect
Figure 7
(a) Depicted that NSAID treatment provoked oxidative stress as well as inflammatory response and hampared prostaglandin production, resulting to formation of mucosal damage, ultimately ulcer. However, treatment of eAE at the dose of 60 mg/kg b.w helped to release the oxidative stress which in turn upregulate PGE2 status, IL-10 level.On the other hand treatment of amla at 40 mg/kg and 120 mg/kg b.w shows acute toxicity by provoking more ROS generation as well as imbalance pro/anti-inflammatory cytokines ratio. (b) Depicted that amla is good for health and it has no toxic effect in normal stomach at higher dose.
