Assessment of the Antioxidant and Reactive Oxygen Species Scavenging Activity of Methanolic Extract of Caesalpinia crista Leaf
Figure 9
Role of C. crista in prevention of diseases caused by free radicals. Generation of ROS and reactive nitrogen species (RNS) is initiated by respiratory burst, which is set off by various physiological and environmental factors. The fabrication of an assortment of ROS and RNS from the molecular O2 and L-arginine, respectively, carried on by different enzymes like MPO (myloperoxidase), NADPH oxidase, SOD (superoxide dismutase) and NOS (nitric oxide synthase) leads to diverse cellular phenomena, namely, damage of DNA-repair proteins and caspases, lipid peroxydation, DNA damage followed by mutation and NF-κB activation. All these phenomena give rise to wide range of diseases. Caesalpinia crista leaf extract inhibits the generations of the free radicals by scavenging both the mother and the daughter products and also by inducing the increase of SOD, CAT, GST and GSH, resulting the obstruction of various disease formation.
