TY - JOUR
AU - Montoro, A.
AU - Barquinero, J. F.
AU - Almonacid, M.
AU - Montoro, A.
AU - Sebastià, N.
AU - Verdú, G.
AU - Sahuquillo, V.
AU - Serrano, J.
AU - Saiz, M.
AU - Villaescusa, J. I.
AU - Soriano, J. M.
PY - 2011
DA - 2010/10/11
TI - Concentration-Dependent Protection by Ethanol Extract of Propolis against γ-Ray-Induced Chromosome Damage in Human Blood Lymphocytes
SP - 174853
VL - 2011
AB - Radioprotection with natural products may be relevant to the mitigation of ionizing radiation-induced damage in mammalian systems; in this sense, propolis extracts have shown effects such as antioxidant, antitumoral, anti-inflammatory, and immunostimulant. We report for the first time a cytogenetic study to evaluate the radioprotective effect, in vitro, of propolis against radiation-induced chromosomal damage. Lymphocytes were cultured with increasing concentrations of ethanol extract of propolis (EEP), including 20, 40, 120, 250, 500, 750, 1000, and 2000 μg mL−1 and then exposed to 2 Gy γ-rays. A significant and concentration-dependent decrease is observed in the frequency of chromosome aberrations in samples treated with EEP. The protection against the formation of dicentrics was concentration-dependent, with a maximum protection at 120 μg mL−1 of EEP. The observed frequency of dicentrics is described as negative exponential function, indicating that the maximum protectible fraction of dicentrics is approximately 44%. Free radical scavenging and antioxidant activities are the mechanisms that these substances use to protect cells from ionizing radiation.
SN - 1741-427X
UR - https://doi.org/10.1155/2011/174853
DO - 10.1155/2011/174853
JF - Evidence-Based Complementary and Alternative Medicine
PB - Hindawi Publishing Corporation
KW -
ER -