Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 185918, 11 pages
http://dx.doi.org/10.1093/ecam/nep014
Original Article

Brazilian Green Propolis: Effects In Vitro and In Vivo on Trypanosoma cruzi

1Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos 21045-900, Rio de Janeiro, Brazil
2Laboratório de Biologia Estrutural, Instituto Oswaldo Cruz, FIOCRUZ, CP 926, 21045-900, Rio de Janeiro, Brazil

Received 12 November 2008; Accepted 16 January 2009

Copyright © 2011 Kelly Salomão et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. WHO, “Control of Chagas disease,” Technical Report Series, vol. 905, pp. 1–109, 2002. View at Google Scholar
  2. J. R. Coura and S. L. De Castro, “A critical review on Chagas disease chemotherapy,” Memórias do Instituto Oswaldo Cruz, vol. 97, pp. 3–24, 2002. View at Google Scholar
  3. J. Jannin and L. Villa, “An overview of Chagas disease treatment,” Memórias do Instituto Oswaldo Cruz, vol. 102, pp. 95–97, 2007. View at Google Scholar
  4. E. Prytzyk, A. P. Dantas, K. Salomão et al., “Flavonoids and trypanocidal activity of Bulgarian propolis,” Journal of Ethnopharmacology, vol. 88, pp. 189–193, 2003. View at Google Scholar
  5. K. Salomão, A. P. Dantas, C. M. Borba et al., “Chemical composition and microbicidal activity of extracts from Brazilian and Bulgarian propolis,” Letters in Applied Microbiology, vol. 38, pp. 87–92, 2004. View at Google Scholar
  6. A. P. Dantas, K. Salomão, H. S. Barbosa, and S. L. De Castro, “The effect of Bulgarian propolis against Trypanosoma cruzi and during its interaction with host cells,” Memórias do Instituto Oswaldo Cruz, vol. 101, pp. 207–211, 2006. View at Google Scholar
  7. S. L. De Castro, “Propolis: biological and pharmacological activities. Therapeutic uses of this bee-product,” Annual Review of Biomedical Sciences, vol. 3, pp. 49–83, 2001. View at Google Scholar
  8. M. C. Marcucci and V. S. Bankova, “Chemical composition, plant origin and biological activity of Brazilian propolis,” Current Topics in Phytochemistry, vol. 2, pp. 115–123, 1999. View at Google Scholar
  9. L. B. Sy, Y. L. Wu, B. L. Chiang, Y. H. Wang, and W. M. Wu, “Propolis extracts exhibit an immunoregulatory activity in an OVA-sensitized airway inflammatory animal model,” International Immunopharmacology, vol. 6, pp. 1053–1060, 2006. View at Google Scholar
  10. A. Sabir, C. R. Tabbu, P. Agustiono, and W. Sosroseno, “Histological analysis of rat dental pulp tissue capped with propolis,” Journal of Oral Science, vol. 47, pp. 135–138, 2005. View at Google Scholar
  11. J. Starzyk, S. Scheller, J. Szaflarski, M. Moskwa, and A. Stojko, “Biological properties and clinical application of propolis. II. Studies on the antiprotozoan activity of ethanol extract of propolis,” Arzneimittel-Forschung, vol. 27, pp. 1198–1199, 1977. View at Google Scholar
  12. R. Padmavathi, P. Senthilnathan, D. Chodon, and D. Sakthisekaran, “Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12-dimethyl benz(a)anthracene-induced breast cancer in female Sprague Dawley rats,” Life Science, vol. 78, pp. 2820–2825, 2006. View at Google Scholar
  13. A. S. El-Khatib, A. M. Agha, L. G. Mahran, and M. T. Khayyal, “Prophylactic effect of aqueous propolis extract against acute experimental hepatotoxicity in vivo,” Zeitschrift für Naturforschung, vol. 57C, pp. 379–385, 2002. View at Google Scholar
  14. H. Ichikawa, K. Satoh, T. Tobe et al., “Free radical scavenging activity of propolis,” Redox Report, vol. 7, pp. 347–350, 2002. View at Google Scholar
  15. I. Jasprica, A. Mornar, Z. Debeljak et al., “In vivo study of propolis supplementation effects on antioxidative status and red blood cells,” Journal of Ethnopharmacology, vol. 110, pp. 548–554, 2007. View at Google Scholar
  16. A. Arvouet-Grand, B. Lejeune, P. Bastide, A. Pourrat, A. M. Privat, and P. Legret, “Propolis extract. I. Acute toxicity and determination of acute primary cutaneous irritation index,” Journal de Pharmacie de Belgique, vol. 48, pp. 165–170, 1993. View at Google Scholar
  17. I. Hollands, A. Vidal, and M. Sotolongo, “Evaluation of the sub-chronic toxicity of Cuban propolis,” Revista Cubana Ciencias Veterinarias, vol. 1, pp. 157–163, 1991. View at Google Scholar
  18. M. C. Marcucci, “Process to typing natural products,” Requested patent. Brazilian National Institute for Intellectual Property (INPI), n, PI 0105471-6, December 2000.
  19. N. Paulino, C. Teixeira, R. Martins et al., “Evaluation of the analgesic and anti-inflammatory effects of Brazilian green propolis,” Planta Medica, vol. 72, pp. 899–906, 2006. View at Google Scholar
  20. N. Paulino, A. P. Dantas, V. S. Bankova et al., “Bulgarian propolis induces analgesic and anti-inflammatory effects in mice and inhibits in vitro contraction of airway smooth muscle,” Journal of Pharmacological Sciences, vol. 93, pp. 307–313, 2003. View at Google Scholar
  21. G. M. C. Machado, L. L. Leon, and S. L. De Castro, “Activity of Brazilian and Bulgarian propolis against different species of Leishmania,” Memórias do Instituto Oswaldo Cruz, vol. 102, pp. 73–77, 2007. View at Google Scholar
  22. S. L. De Castro, M. N. L. Meirelles, and M. M. Oliveira, “Trypanosoma cruzi: adrenergic modulation of cAMP role in proliferation and differentiation of amastigotes in vitro,” Experimental Parasitology, vol. 64, pp. 368–375, 1987. View at Google Scholar
  23. R. M. Santa-Rita, R. Lira, H. S. Barbosa, J. A. Urbina, and S. L. De Castro, “Antiproliferative synergism of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis,” Journal of Antimicrobial Chemotherapy, vol. 55, pp. 780–784, 2005. View at Google Scholar
  24. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, pp. 55–63, 1983. View at Google Scholar
  25. Z. Brener, “Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi,” Revista do Instituto de Medicina Tropical de São Paulo, vol. 4, pp. 386–396, 1962. View at Google Scholar
  26. Y. K. Park, S. M. Alencar, and C. L. Aguiar, “Botanical origin and chemical composition of Brazilian propolis,” Journal of Agricultural and Food Chemistry, vol. 50, pp. 2502–2506, 2002. View at Google Scholar
  27. M. C. Marcucci, F. Ferreres, C. Garcia-Viguera et al., “Phenolic compounds from Brazilian propolis with pharmacological activities,” Journal of Ethnopharmacology, vol. 74, pp. 105–112, 2001. View at Google Scholar
  28. C. Sant'Anna, M. G. Pereira, L. Lemgruber, W. de Souza, and N. L. Cunha-e-Silva, “New insights into the morphology of Trypanosoma cruzi reservosome,” Microscopy Research and Technique, vol. 71, pp. 599–605, 2008. View at Google Scholar
  29. M. J. Soares, “Endocytic portals in Trypanosoma cruzi epimastigote forms,” Parasitology Research, vol. 99, pp. 321–322, 2006. View at Google Scholar
  30. R. C. Figueiredo, D. S. Rosa, and M. J. Soares, “Differentiation of Trypanosoma cruzi epimastigotes: metacyclogenesis and adhesion to substrate are triggered by nutritional stress,” Journal of Parasitology, vol. 86, pp. 1213–1218, 2000. View at Google Scholar
  31. N. Cunha-e-Silva, C. Sant'Anna, M. G. Pereira, I. Porto-Carreiro, A. L. Jeovanio, and W. De Souza, “Reservosomes: multipurpose organelles?” Parasitology Research, vol. 99, pp. 325–327, 2006. View at Google Scholar
  32. R. F. S. Menna-Barreto, K. Salomão, A. P. Dantas et al., “Different cell death pathways induced by drugs in Trypanosoma cruzi: an ultrastructural study,” Micron, vol. 40, pp. 157–168, 2009. View at Google Scholar
  33. D. A. Oliveira, D. G. Pereira, A. M. A. P. Fernandes et al., “Trypanocidal activity of 2-propen-1-amine derivatives on trypomastigotes culture and in animal model,” Parasitology Research, vol. 95, pp. 161–166, 2005. View at Google Scholar
  34. A. P. Souza, B. P. Olivieri, S. L. De Castro, and T. C. Araújo-Jorge, “Enzymatic markers of heart lesion in mice infected with Trypanosoma cruzi and submitted to benznidazole chemotherapy,” Parasitology Research, vol. 86, pp. 800–808, 2000. View at Google Scholar
  35. J. M. Sforcin, “Propolis and the immune systemml: a review,” Journal of Ethnopharmacology, vol. 113, pp. 1–4, 2007. View at Google Scholar