Original Article

A Chinese Herbal Medicine, Tokishakuyakusan, Reduces the Worsening of Impairments and Independence after Stroke: A 1-Year Randomized, Controlled Trial

Table 3

Comparison between TS and control groups on each item of SIAS.

VariableRangeTS groupControl groupP-valuea
Baseline12 monthsBaseline12 months

Knee-mouse0–52.53 ± 1.922.40 ± 0.512.13 ± 1.771.73 ± 1.75*.295
Finger-function0–52.33 ± 1.762.27 ± 1.871.87 ± 1.551.40 ± 1.35*.197
Hip-function0–52.40 ± 1.502.27 ± 1.582.33 ± 1.401.80 ± 1.37**.262
Knee-extension0–52.27 ± 1.442.27 ± 1.392.13 ± 1.461.40 ± 1.12**<.001
Foot-pat0–52.33 ± 1.452.27 ± 1.392.27 ± 1.671.73 ± 1.44**.018
DTR0–31.83 ± 0.981.90 ± 0.872.10 ± 0.812.00 ± 0.78.106
Tone0–32.10 ± 1.041.83 ± 1.102.10 ± 0.812.00 ± 0.80.670
Touch0–32.30 ± 0.752.13 ± 0.742.17 ± 0.771.83 ± 0.92.237
Position0–31.87 ± 1.061.87 ± 1.131.97 ± 0.901.77 ± 0.98.219
Range of motion0–31.87 ± 1.061.87 ± 1.131.97 ± 0.901.76 ± 0.98.219
Pain0–32.53 ± 0.642.47 ± 0.642.73 ± 0.462.73 ± 0.46.560
Abdominal MMT0–31.40 ± 1.061.67 ± 1.18*1.33 ± 0.821.20 ± 0.86.004
Verticality0–32.27 ± 0.802.13 ± 0.992.07 ± 0.591.73 ± 0.88*.359
Visuo-spat. score0–31.67 ± 1.351.80 ± 1.421.67 ± 0.981.33 ± 1.18*.031
Speech0–32.00 ± 0.931.87 ± 0.921.73 ± 0.701.40 ± 0.74.681
Unaffected quadriceps0–31.80 ± 0.781.87 ± 0.741.93 ± 0.701.53 ± 0.83*.022
Unaffected grip power (kg)8.93 ± 6.208.07 ± 6.3110.7 ± 7.168.80 ± 7.67.671

DTR, deep tender reflexes; MMT, manual muscle testing; Visuo-spat., visuospatial perception.
aComparison of 12-month changes between TS group and control group.
* P <  .05, **P <  .01, Comparison between baseline and at 12 months in the same group.