Electroacupuncture Inhibits Inflammation Reaction by Upregulating Vasoactive Intestinal Peptide in Rats with Adjuvant-Induced Arthritis

<table>A hypothetical diagram illustrating the EA action mediated by VIP in adjuvant-induced arthritis. EA stimulation at specific acupoints promotes the expression and release of VIP, which in turn suppresses the production of proinflammatory cytokines and chemokines (e.g., MCP-1, IL-6, and IL-8) by synovial cells and/or induces regulatory T cells (Treg) expansion, ultimately leading to the inhibition of lymphocyte proliferation, activation, and infiltration and the alleviation of inflammatory responses.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 9

Figure 9: Electroacupuncture Inhibits Inflammation Reaction by Upregulating Vasoactive Intestinal Peptide in Rats with Adjuvant-Induced Arthritis 