Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Tab 1 / Original Article
A Chinese Herbal Decoction, Danggui Buxue Tang, Stimulates Proliferation, Differentiation and Gene Expression of Cultured Osteosarcoma Cells: Genomic Approach to Reveal Specific Gene Activation Table 1 Genes related to bone development are up regulated by DBT.
Regulated genea Symbol Genbank no. Fold of changeb DBT RAS RA Lectin, galactoside-binding, soluble, 9 (Galectin-9) LGALS9/Gal-9 AA434102 441.76 1.60 1.77 Small inducible cytokine subfamily A, member 8 SCYA8/CCL-8 AI268937 184.65 2.73 2.89 Small inducible cytokine A7 SCYA7/CCL-7 AA040170 175.02 0.33 6.96 Small inducible cytokine A2 SCYA2/CCL-2 AA425102 88.22 2.35 6.87 Collagen, type XVIII, α 1 COL18α 1 N81029 4.49 5.03 3.99 Matrix metalloproteinase 9 MMP9 T72581 3.87 5.78 7.15 Collagen, type X, α 1 COL10α 1 AI828306 3.44 4.09 13.95 Transforming growth factor, β 2 TGFβ 2 AA233738 2.60 3.40 1.77 Insulin-like growth factor 1 IGF1 AA456321 2.47 — — Bone morphogenetic protein 1 BMP1 R56774 2.29 2.88 6.66 Epidermal growth factor EGF AI480081 2.00 1.19 — Integrin, α 2 ITGα 2 AA463257 1.87 0.75 0.85 Msh (Drosophila ) homeo box homolog 2 MSX2 AA195636 1.86 1.14 0.82 Collagen, type VII, α 1 COL7α 1 AA598507 1.86 3.49 1.76 Bone morphogenetic protein 6 BMP6 AA424833 1.73 2.28 1.27 Msh (Drosophila) homeo box homolog 1 MSX1 AA464197 1.66 1.45 1.28 Fibroblast growth factor receptor 3 FGFR3 AA419620 1.65 0.97 0.82 Cartilage oligomeric matrix protein COMP N94385 1.64 1.30 4.82 Transforming growth factor, β 1 TGFβ 1 R36467 1.56 1.94 2.00 Bone morphogenetic protein 8 BMP8 AA779480 1.41 1.73 1.30 Bone morphogenetic protein 7 BMP7 W73473 1.39 1.75 1.64 Fibroblast growth factor receptor 1 FGFR1 R54846 1.36 1.17 1.25 Multiple inositol polyphosphate phosphatase 1 MINPP1 AA161161 0.29 0.47 0.57
a Genes known to play role in bone development are selected for illustration; b Change of gene expressions as compared to the control (no drug treatment). “—” below detection.