Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents

Table 2

Effect of a forty-day oral administration of Corrigiola telephiifolia root extract in rats.

Dose of CT extract^a (mg/kg)	Sex	D/T^b	Symptoms	Duration of symptoms
0	M	0/8	None	—
	F	0/8	None	—
5	M	0/8	Slight abdominal contractions^c	—
	F	0/8	Slight abdominal contractions^c	—
70	M	0/8	(i) Abdominal contractions^c	—
			(ii) Hypoactivity, hunched posture, loss of appetite, mild diarrhea.	1 week
			(iii) Polyuria, yellow feces.	5 weeks
	F	0/8	(i) Abdominal contractions^c	—
			(ii) Hypoactivity, hunched posture, loss of appetite, mild diarrhea.	2 weeks
			(iii) Polyuria, yellow feces.	5 weeks
2000	M	0/8	(i) Abdominal contractions^c	—
			(ii) Hypoactivity, hunched posture, loss of appetite, mild diarrhea.	2-3 weeks
			(iii) Polyuria, yellow feces	5 weeks
	F	0/8	(i) Abdominal contractions^c	—
			(ii) Marked hypoactivity, hunched posture, loss of appetite, intense diarrhea,	4 weeks
			(iii) Respiratory difficulties for 2 rats	1 week
			(iv) Polyuria, yellow feces	5 weeks

^a𝐶orrigiola telephiifolia extract was administered as a reiterated dose to groups of rats for forty days.
^bD/T: dead /treated rats.
^cThe abdominal contractions were noted only after the oral administration of the extract.