Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model
Figure 3
Immunohistochemical studies showed that the expression of HIF-1α of the high-dose hachimijiogan group increased compared to that of the control group (a–e). The black arrow indicates an HIF-1α-positive cell stained brown, and the white arrow indicates an HIF-1α-negative cell stained blue. The number of HIF-1α-positive cells in the high-dose hachimijiogan group increased significantly compared to that in the control group. (a) sham, (b) control, (c) low-dose hachimijiogan, (d) high-dose hachimijiogan, (e) candesartan cilexetil. (magnification 400x, scale bar: 100 μm), (f) Comparison with percentage of HIF-1α-positive cells/field in the every group. Data represent mean ± S.D. , versus sham group, versus control group.