Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 367619, 7 pages
http://dx.doi.org/10.1093/ecam/nep218
Original Article

Total Flavonoids Extracted from Xiaobuxin-Tang on the Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis in Chronically Stressed Rats

1Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
2College of pharmacy, Dalian Medical University, Dalian 116044, China
3Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100094, China

Received 15 April 2009; Accepted 25 November 2009

Copyright © 2011 Lei An et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. F. Juruena, A. J. Cleare, and C. M. Pariante, “The hypothalamic pituitary adrenal axis, glucocorticoid receptor function and relevance to depression,” Revista Brasileira de Psiquiatria, vol. 26, no. 3, pp. 189–201, 2004. View at Google Scholar · View at Scopus
  2. C. M. Pariante and S. L. Lightman, “The HPA axis in major depression: classical theories and new developments,” Trends in Neurosciences, vol. 31, no. 9, pp. 464–468, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Ito, T. Nagai, T. Oikawa, H. Yamada, and T. Hanawa, “Antidepressant-like effect of l-perillaldehyde in stress-induced depression-like model mice through regulation of the olfactory nervous system,” Evidence-Based Complementary and Alternative Medicine, 2008. View at Publisher · View at Google Scholar
  4. S.-H. Kim, J. Han, D.-H. Seog et al., “Antidepressant effect of Chaihu-Shugan-San extract and its constituents in rat models of depression,” Life Sciences, vol. 76, no. 11, pp. 1297–1306, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. J.-M. Li, L.-D. Kong, Y.-M. Wang, C. H. K. Cheng, W.-Y. Zhang, and W.-Z. Tan, “Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction,” Life Sciences, vol. 74, no. 1, pp. 55–73, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. W. E. Müller, “Current St. John's wort research from mode of action to clinical efficacy,” Pharmacological Research, vol. 47, no. 2, pp. 101–109, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. Y.-Z. Zhang, N.-J. Yu, L. Yuan et al., “Antidepressant effect of total flavonoids extracted from Xiaobuxin-Tang in forced swimming tests and learned helplessness in rats and mice,” Chinese Journal of Pharmacology and Toxicology, vol. 22, no. 1, pp. 1–8, 2008. View at Google Scholar · View at Scopus
  8. L. An, Y.-Z. Zhang, N.-J. Yu et al., “Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang,” Pharmacology Biochemistry and Behavior, vol. 89, no. 4, pp. 572–580, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. L. An, Y. Z. Zhang, N. J. Yu, X. M. Liu, N. Zhao, and L. Yuan, “The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, pp. 1484–1490, 2008. View at Google Scholar
  10. I. Heuser, “The hypothalamic-pituitary-adrenal system in depression,” Pharmacopsychiatry, vol. 31, no. 1, pp. 10–13, 1998. View at Google Scholar · View at Scopus
  11. P. Linkowski, J. Mendlewicz, R. LeClerc, M. Brasseur, P. Hubain, and J. Goldstein, “The 24-hour profile of ACTH and cortisol in major depressive illness,” Journal of Clinical Endocrinology and Metabolism, vol. 61, pp. 429–438, 1985. View at Google Scholar
  12. C. Heim and C. B. Nemeroff, “Neurobiology of early life stress: clinical studies,” Seminars in Clinical Neuropsychiatry, vol. 7, no. 2, pp. 147–159, 2002. View at Google Scholar · View at Scopus
  13. B. Weber, S. Lewicka, M. Deuschle, M. Colla, P. Vecsei, and I. Heuser, “Increased diurnal plasma concentrations of cortisone in depressed patients,” Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 3, pp. 1133–1136, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. V. Butterweck, M. Hegger, and H. Winterhoff, “Flavonoids of St. John's Wort reduce HPA axis function in the rat,” Planta Medica, vol. 70, no. 10, pp. 1008–1011, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Willner, “Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS,” Neuropsychobiology, vol. 52, no. 2, pp. 90–110, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. J. P. Brouwer, B. C. Appelhof, E. F. C. van Rossum et al., “Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression,” Psychoneuroendocrinology, vol. 31, no. 10, pp. 1154–1163, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Holsboer and N. Barden, “Antidepressants and hypothalamic-pituitary-adrenocortical regulation,” Endocrine Reviews, vol. 17, no. 2, pp. 187–205, 1996. View at Publisher · View at Google Scholar · View at Scopus
  18. B. L. Mason and C. M. Pariante, “The effects of antidepressants on the hypothalamic-pituitary-adrenal axis,” Drug News and Perspectives, vol. 19, no. 10, pp. 603–608, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. C. M. Pariante, “The glucocorticoid receptor: part of the solution or part of the problem?” Journal of Psychopharmacology, vol. 20, no. 4, pp. 79–84, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Thomson and M. Craighead, “Innovative approaches for the treatment of depression: targeting the HPA axis,” Neurochemical Research, vol. 33, no. 4, pp. 691–707, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. M. J. Webster, M. B. Knable, J. O'Grady, J. Orthmann, and C. S. Weickert, “Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders,” Molecular Psychiatry, vol. 7, no. 9, pp. 985–994, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Chourbaji, M. A. Vogt, and P. Gass, “Mice that under- or overexpress glucocorticoid receptors as models for depression or posttraumatic stress disorder,” Progress in Brain Research, vol. 167, pp. 65–77, 2008. View at Google Scholar
  23. B. Budziszewska, J. Siwanowicz, and E. Przegalinski, “The effect of chronic treatment with antidepressant drugs on the corticosteroid receptor levels in the rat hippocampus,” Polish Journal of Pharmacology, vol. 46, no. 3, pp. 147–152, 1994. View at Google Scholar · View at Scopus
  24. A. Peiffer, S. Veilleux, and N. Barden, “Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain,” Psychoneuroendocrinology, vol. 16, pp. 505–515, 1991. View at Google Scholar
  25. E. Przegaliñski, B. Budziszewska, J. Siwanowicz, and L. Jaworska, “The effect of repeated combined treatment with nifedipine and antidepressant drugs or electroconvulsive shock on the hippocampal corticosteroid receptors in rats,” Neuropharmacology, vol. 32, pp. 1397–1400, 1993. View at Google Scholar
  26. J. R. Seckl and G. Fink, “Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo,” Neuroendocrinology, vol. 55, no. 6, pp. 621–626, 1992. View at Google Scholar · View at Scopus
  27. G. Xu, H. Zhang, and J. Hu, “Leaching method of flavone from bamboo leaves,” Fenxi Huaxue, vol. 28, no. 7, pp. 857–859, 2000. View at Google Scholar · View at Scopus
  28. J. Grønli, R. Murison, E. Fiske et al., “Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions,” Physiology and Behavior, vol. 84, no. 4, pp. 571–577, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Willner, “Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation,” Psychopharmacology, vol. 134, no. 4, pp. 319–329, 1997. View at Publisher · View at Google Scholar · View at Scopus
  30. B. Vollmayr and F. A. Henn, “Stress models of depression,” Clinical Neuroscience Research, vol. 3, no. 4-5, pp. 245–251, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Budziszewska, “Effect of antidepressant drugs on the hypothalamic-pituitary-adrenal axis activity and glucocorticoid receptor function,” Polish Journal of Pharmacology, vol. 54, no. 4, pp. 343–349, 2002. View at Google Scholar · View at Scopus
  32. C. Pittenger and R. S. Duman, “Stress, depression, and neuroplasticity: a convergence of mechanisms,” Neuropsychopharmacology, vol. 33, no. 1, pp. 88–109, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. P. J. Lucassen, M. B. Müller, F. Holsboer et al., “Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure,” American Journal of Pathology, vol. 158, no. 2, pp. 453–468, 2001. View at Google Scholar · View at Scopus
  34. K. Mizoguchi, M. Yuzurihara, A. Ishige, H. Sasaki, D.-H. Chui, and T. Tabira, “Chronic stress differentially regulates glucocorticoid negative feedback response in rats,” Psychoneuroendocrinology, vol. 26, no. 5, pp. 443–459, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. M. E. Paskitti, B. J. McCreary, and J. P. Herman, “Stress regulation of adrenocorticosteroid receptor gene transcription and mRNA expression in rat hippocampus: time-course analysis,” Brain Research. Molecular Brain Research, vol. 80, pp. 142–152, 2000. View at Google Scholar
  36. W. J. Cubała and J. Landowski, “Serotoninergic system and limbic-hypothalamic-pituitary-adrenal axis (LHPA axis) in depression,” Psychiatria Polska, vol. 40, no. 3, pp. 415–430, 2006. View at Google Scholar · View at Scopus
  37. L. Lanfumey, R. Mongeau, C. Cohen-Salmon, and M. Hamon, “Corticosteroid-serotonin interactions in the neurobiological mechanisms of stress-related disorders,” Neuroscience and Biobehavioral Reviews, vol. 32, no. 6, pp. 1174–1184, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Takeda, M. Tsuji, and T. Matsumiya, “Formation mechanisms of stress adaptation: role of functional coupling of glucocorticoids and brain serotonergic nervous system,” Nihon Shinkei Seishin Yakurigaku Zasshi, vol. 20, pp. 83–91, 2000. View at Google Scholar
  39. M. Colla, G. Kronenberg, M. Deuschle et al., “Hippocampal volume reduction and HPA-system activity in major depression,” Journal of Psychiatric Research, vol. 41, no. 7, pp. 553–560, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. J. Herbert, I. M. Goodyer, A. B. Grossman et al., “Do corticosteroids damage the brain?” Journal of Neuroendocrinology, vol. 18, no. 6, pp. 393–411, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. R. M. Sapolsky, “Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders,” Archives of General Psychiatry, vol. 57, no. 10, pp. 925–935, 2000. View at Google Scholar · View at Scopus