Review Article
Genome-Based Studies of Marine Microorganisms to Maximize the Diversity of Natural Products Discovery for Medical Treatments
Table 1
Active natural products isolated from marine microorganisms.
| Metabolites | Source | Activity | Reference | Clinical status |
| Soblidotin (TZT1027) | Synthetic derivative of dolastatin 10 isolated from marine cyanobacterium Symploca sp. VP642 | Anticancer | [12] | Phase III | Plinabulin (NPI-2358) | Synthetic analog of halimide isolated from the marine fungus Aspergillus sp. CNC-139 | Anticancer | [13] | Phase II | Bryostatin 1 | Identified from bryozoan and also marine symbiotic bacteria Candidatus Endobugula sertula | Anticancer, Anti-Alzheimer | [14] | Phase I | Marizomib (salinosporamide A, NPI-0052) | Marine actinobacteria Salinispora arenicola | Anticancer | [15] | Phase I | Compound 4 (curacin A synthetic derivative) | Curacin A was isolated from the marine cyanobacterium Lyngbya majuscula | Anticancer | [16] | Preclinical |
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