Review Article

Genome-Based Studies of Marine Microorganisms to Maximize the Diversity of Natural Products Discovery for Medical Treatments

Table 1

Active natural products isolated from marine microorganisms.

MetabolitesSourceActivityReferenceClinical status

Soblidotin (TZT1027)Synthetic derivative of dolastatin 10 isolated from marine cyanobacterium Symploca sp. VP642Anticancer[12]Phase III
Plinabulin (NPI-2358)Synthetic analog of halimide isolated from the marine fungus Aspergillus sp. CNC-139Anticancer[13]Phase II
Bryostatin 1Identified from bryozoan and also marine symbiotic bacteria Candidatus Endobugula sertula Anticancer, Anti-Alzheimer[14]Phase I
Marizomib (salinosporamide A, NPI-0052)Marine actinobacteria Salinispora arenicola Anticancer[15]Phase I
Compound 4 (curacin A synthetic derivative)Curacin A was isolated from the marine cyanobacterium Lyngbya majuscula Anticancer[16]Preclinical