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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 430237, 6 pages
Research Article

Metabolic Profile of Offspring from Diabetic Wistar Rats Treated with Mentha piperita (Peppermint)

1Department of Biochemistry, Faculty of Medicine, UNIMAR, 17500-021 Marília, SP, Brazil
2Department of Biochemistry, Faculty of Technology and Foods of Marília (FATEC), 17506-000 Marília, SP, Brazil
3Laboratory of Experimental Research of Gynecology and Obstetrics, Medical School, São Paulo University Julio de Mesquita Filho (UNESP-Botucatu), 18607-741 Botucatu, SP, Brazil
4Department of Biochemistry, University of São Paulo (USP), 05508-900 São Paulo, SP, Brazil
5Department of Biochemistry, Methodist Unversity of Piracicaba (UNIMEP), 16400-680 Lins, SP, Brazil
6Department of Nutrition, Frigorificos Friboi S/A, Industrial Park, 116400-000 Lins, SP, Brazil

Received 24 November 2010; Revised 31 January 2011; Accepted 24 February 2011

Copyright © 2011 Sandra M. Barbalho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study aimed at evaluating glycemia and lipid profile of offspring from diabetic Wistar rats treated with Mentha piperita (peppermint) juice. Male offspring from nondiabetic dams (control group: 10 animals treated with water and 10 treated with peppermint juice) and from dams with streptozotocin-induced severe diabetes (diabetic group: 10 animals treated with water and 10 treated with peppermint juice) were used. They were treated during 30 days, and, after the treatment period, levels of glycemia, triglycerides, total cholesterol, and fractions were analyzed in the adult phase. The offspring from diabetic dams treated with peppermint showed significantly reduced levels of glucose, cholesterol, LDL-c, and triglycerides and significant increase in HDL-c levels. The use of the M. piperita juice has potential as culturally appropriate strategy to aid in the prevention of DM, dyslipidemia, and its complications.