Biphasic Effect of Curcumin on Morphine Tolerance: A Preliminary Evidence from Cytokine/Chemokine Protein Array Analysis

<table>Biphasic effect of curcumin on morphine tolerance. After a 7-day drug intervention, AD<sub>50</sub> values calculated from the cumulative dose-response curve on Day 8 showed that low-dose curcumin attenuates morphine tolerance but high-dose curcumin aggravates it.</table>

Evidence-Based Complementary and Alternative Medicine

fig6

Figure 6

Figure 6: Biphasic Effect of Curcumin on Morphine Tolerance: A Preliminary Evidence from Cytokine/Chemokine Protein Array Analysis 