Biphasic Effect of Curcumin on Morphine Tolerance: A Preliminary Evidence from Cytokine/Chemokine Protein Array Analysis

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left">Chronic treatment</td><td align="center">AD<sub>50</sub> (mg kg<sup>-1</sup>)</td><td align="center">95% CI</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Morphine-Normal saline</td><td align="center">28.0</td><td align="center">21.5–34.5</td></tr><tr><td align="left">Morphine-DMSO</td><td align="center">29.5</td><td align="center">20.0–39.0</td></tr><tr><td align="left">Morphine-25 mg kg<sup>-1</sup> Curcumin</td><td align="center">13.0</td><td align="center">7.63–18.5</td></tr><tr><td align="left">Morphine-400 mg kg<sup>-1</sup> Curcumin</td><td align="center">98.1</td><td align="center">73.2–122</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>After 7 days of chronic treatment period, cumulative dose-response curves to acute morphine were generated on Day 8. AD<sub>50</sub> were derived from these curves in Figure <a href="../fig5/">5</a> CI represents confidence interval.<br/></td></tr></table>

Effects of DMSO and curcumin on the development of morphine tolerance.

Evidence-Based Complementary and Alternative Medicine

tab1

Table 1

Table 1: Biphasic Effect of Curcumin on Morphine Tolerance: A Preliminary Evidence from Cytokine/Chemokine Protein Array Analysis 