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Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 459531, 8 pages
http://dx.doi.org/10.1155/2011/459531
Research Article

A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway

1School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
2Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan
3Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan
4Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan

Received 9 April 2010; Revised 12 August 2010; Accepted 16 August 2010

Copyright © 2011 Hung-Jen Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. L. Friedman, “Liver fibrosis—from bench to bedside,” Journal of Hepatology, vol. 38, no. 1, pp. S38–S53, 2003. View at Google Scholar · View at Scopus
  2. R. Bataller and D. A. Brenner, “Liver fibrosis,” Journal of Clinical Investigation, vol. 115, no. 2, pp. 209–218, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. J. P. Iredale, “Hepatic stellate cell behavior during resolution of liver injury,” Seminars in Liver Disease, vol. 21, no. 3, pp. 427–436, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. S. L. Friedman, “Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury,” Journal of Biological Chemistry, vol. 275, no. 4, pp. 2247–2250, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Tsukada, C. J. Parsons, and R. A. Rippe, “Mechanisms of liver fibrosis,” Clinica Chimica Acta, vol. 364, no. 1-2, pp. 33–60, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. M. J. P. Arthur, “Reversibility of liver fibrosis and cirrhosis following treatment for hepatitis C,” Gastroenterology, vol. 122, no. 5, pp. 1525–1528, 2002. View at Google Scholar · View at Scopus
  7. S. L. Friedman and M. B. Bansal, “Reversal of hepatic fibrosis—fact or fantasy?” Hepatology, vol. 43, no. 2, pp. S82–S88, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Kisseleva and D. A. Brenner, “Hepatic stellate cells and the reversal of fibrosis,” Journal of Gastroenterology and Hepatology, vol. 21, no. 3, pp. S84–S87, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Wu and M. A. Zern, “Hepatic stellate cells: a target for the treatment of liver fibrosis,” Journal of Gastroenterology, vol. 35, no. 9, pp. 665–672, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. S. L. Friedman, “Mechanisms of hepatic fibrogenesis,” Gastroenterology, vol. 134, no. 6, pp. 1655–1669, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Mu, P. Liu, G. Du et al., “Action mechanism of Yi Guan Jian Decoction on CCl4 induced cirrhosis in rats,” Journal of Ethnopharmacology, vol. 121, no. 1, pp. 35–42, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. J.-C. Cheng, M.-F. Chang, and S. C. Chang, “Specific interaction between the hepatitis C virus NS5B RNA polymerase and the 3' end of the viral RNA,” Journal of Virology, vol. 73, no. 8, pp. 7044–7049, 1999. View at Google Scholar · View at Scopus
  13. S.-Y. Wang, C.-P. Tseng, K.-C. Tsai et al., “Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq,” Biochemical and Biophysical Research Communications, vol. 385, no. 2, pp. 230–235, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Zhang, X. Qi, L. Gong et al., “Roles of reactive oxygen species and MAP kinases in the primary rat hepatocytes death induced by toosendanin,” Toxicology, vol. 249, no. 1, pp. 62–68, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Orrenius, V. Gogvadze, and B. Zhivotovsky, “Mitochondrial oxidative stress: implications for cell death,” Annual Review of Pharmacology and Toxicology, vol. 47, pp. 143–183, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Liu, W. Wei, W.-Y. Sun, and X. Li, “Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells,” Journal of Ethnopharmacology, vol. 122, no. 3, pp. 502–508, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. S.-G. Guo, W. Zhang, T. Jiang et al., “Influence of serum collected from rat perfused with compound Biejiaruangan drug on hepatic stellate cells,” World Journal of Gastroenterology, vol. 10, no. 10, pp. 1487–1494, 2004. View at Google Scholar · View at Scopus
  18. K. Kayano, I. Sakaida, K. Uchida, and K. Okita, “Inhibitory effects of the herbal medicine Sho-saiko-to (TJ-9) on cell proliferation and procollagen gene expressions in cultured rat hepatic stellate cells,” Journal of Hepatology, vol. 29, no. 4, pp. 642–649, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. S. M. Harwood, M. M. Yaqoob, and D. A. Allen, “Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis,” Annals of Clinical Biochemistry, vol. 42, no. 6, pp. 415–431, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. W. Dröge, “Free radicals in the physiological control of cell function,” Physiological Reviews, vol. 82, no. 1, pp. 47–95, 2002. View at Google Scholar · View at Scopus
  21. M. Valko, D. Leibfritz, J. Moncol, M. T. D. Cronin, M. Mazur, and J. Telser, “Free radicals and antioxidants in normal physiological functions and human disease,” International Journal of Biochemistry and Cell Biology, vol. 39, no. 1, pp. 44–84, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. R. V. Rao, E. Hermel, S. Castro-Obregon et al., “Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation,” Journal of Biological Chemistry, vol. 276, no. 36, pp. 33869–33874, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. X. Jiang and X. Wang, “Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1,” Journal of Biological Chemistry, vol. 275, no. 40, pp. 31199–31203, 2000. View at Google Scholar · View at Scopus
  24. M. P. Mattson and S. L. Chan, “Calcium orchestrates apoptosis,” Nature Cell Biology, vol. 5, no. 12, pp. 1041–1043, 2003. View at Publisher · View at Google Scholar · View at Scopus