Dietary Phenethyl Isothiocyanate Alters Gene Expression in Human Breast Cancer Cells

Table 1

List of genes present in superarrays.

(a) Cancer/tumor suppressor array

APC	Adenomatosis polyposis coli
BRCA1	Breast cancer 1, early onset
BRCA2	Breast cancer 2, early onset
CBP	Human CREB-binding protein
DPC4	Human homozygous deletion target in pancreatic carcinoma (DPC4)
IRF-1	Interferon regulatory factor 1
MSH2	mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1)
NF2	Neurofibromin 2 (bilateral acoustic neuroma)
p18 (cdk4 inhibitor)	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
p19Ink4d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
p21Waf1 (p21Cip1)	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
p27Kip1	Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
p300	CREB-binding protein
p53	Tumor protein p53 (Li-Fraumeni syndrome)
p57Kip2	Cyclin-dependent kinase inhibitor 1C (p57, Kip2)
PTEN	Phosphatase and tensin homolog (mutated in multiple advanced cancers 1
Rb	Retinoblastoma 1 (including osteosarcoma)
TGFbR1 (ALK-5)	Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53 kD)
TGFbR2	Transforming growth factor, beta receptor II (70–80 kD)
TSC-1	Tuberous sclerosis 1
TSC-2	Tuberous sclerosis 2
VHL	Von Hippel-Lindau syndrome
WT1	Wilms tumor 1

(b) Signal transduction pathway array

ATF-2 (creb-2)	cAMP responsive element binding protein 2
bax	BCL2-associated X protein
CD5	T-cell surface glycoprotein CD5
c-fos	Human cellular oncogene c-fos
c-myc	v-myc avian myelocytomatosis viral oncogene homolog
CYP19 (aromatase p450) (p450XIX)	cytochrome P450, subfamily XIX (aromatization of androgens)
egr-1	Early growth response 1
Fas (Apo-1) (CD95)	Tumor necrosis factor receptor superfamily, member 6
gadd45	DNA-damage-inducible transcript 1
hsf1 (tcf5)	HSF1 (TCF5, Heat shock factor protein)
hsp27 (hsp b1)	Heat shock 27 KD protein
hsp90 (CDw52)	Hsp90 (Human mRNA for 90-kDa heat-shock protein)
IκB𝛼 (mad3)	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
IL-2	Interleukin 2
iNOS	Inducible nitric oxide synthase (NOS)
mdm2	Mouse double minute 2, human homolog of; p53-binding protein
NFκB	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
p19^INK4d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
p21^Waf1 (p21^Cip1)	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
p53	Tumor protein p53 (Li-Fraumeni syndrome)
p57^Kip2	Cyclin-dependent kinase inhibitor 1C (p57, Kip2)
pig7	LPS-induced TNF-alpha factor
pig8	etoposide-induced mRNA