Ameliorate Effects of Li-Fu Formula on IL-6-Mediated Cardiac Hypertrophy in Hamsters Fed with a Hyper-Cholesterol Diet

Figure 6

Our proposed hypothesis that cardiac IL-6, MEK-5-ERK-5 and STAT3 hypertrophic pathways and MEK1/2-ERK1/2 non-cardiacmyocyte proliferative pathway are more activated in hyper cholesterol-fed hamster hearts. The eccentric hypertrophy-related pathway, IL-6-related MEK5-ERK5 pathways and MEK1/2-ERK1/2 non-cardiacmyocyte proliferative pathway may play a part of role for developing eccentric cardiac hypertrophy and pathological changes in hyper cholesterol-fed hamster hearts. Dash lines represent possible theoretical pathways but are still unconfirmed. Up arrows and down arrows on the right side represent increases and decreases, respectively.