Intestinal Anti-Inflammatory Activity of Baccharis dracunculifolia in the Trinitrobenzenesulphonic Acid Model of Rat Colitis
Table 2
Effects of B. dracunculifolia extract (5–200 mg kg−1) and sulfasalazine (25 mg kg−1) on damage score, changes in colonic weight/length, diarrhea and adherence incidence in TNBS acute colitis
Group
Damage scorea (0–10)
Colonic weight/lengthb (mg cm−1)
Diarrhoea (%)
Adherence (%)
Non-colitic
0***
82.30 ± 3.86**
0
0
TNBS-control
8.5 (7–9)
146.99 ± 8.78
80.0
50.0
B. dracunculifolia
5 mg kg−1
6.0 (5–8)*
127.44 ± 8.06
50.0
50.0
10 mg kg−1
7.5 (6–8)
127.82 ± 3.94
50.0
66.7
25 mg kg−1
7.5 (5–10)
135.28 ± 6.33
66.7
66.7
50 mg kg−1
6.5 (5–8)*
139.10 ± 9.05
33.3*
0*
100 mg kg−1
6.5 (4–8)
131.53 ± 7.34
83.3
33.3
200 mg kg−1
7.0 (4–8)
134.62 ± 9.11
50.0
33.3
Sulfasalazine
6.0 (2–8)**
133.58 ± 12.38
16.7
50.0
aScore data are expressed as median (range).
bColonic weight data are expressed as mean ± SEM.
*
P < .05; **P < .01; ***P < .001 versus TNBS control group.
