Intestinal Anti-Inflammatory Activity of Baccharis dracunculifolia in the Trinitrobenzenesulphonic Acid Model of Rat Colitis
Table 3
Effects of B. dracunculifolia extract (5–200 mg kg−1) and sulfasalazine (25 mg kg−1) on GSH content, MPO activity and AP activity in TNBS acute colitis
Group
GSH content (nmol g−1 tissue)
MPO activity (U g−1 tissue)
AP activity (mU mg−1 protein)
Non-colitic
1357.5 ± 86.5**
84.2 ± 8.7**
6.24 ± 0.36*
TNBS control
759.6 ± 31.9
684.2 ± 62.8
12.62 ± 1.72
B. dracunculifolia
5 mg kg−1
967.3 ± 55.0*
324.9 ± 89.9**
10.53 ± 1.21
10 mg kg−1
850.3 ± 27.8
532.8 ± 96.3
14.58 ± 1.36
25 mg kg−1
878.5 ± 82.7
576.4 ± 79.8
14.27 ± 2.02
50 mg kg−1
809.4 ± 55.0
216.9 ± 31.6**
6.16 ± 0.63*
100 mg/kg−1
873.8 ± 25.8
245.8 ± 39.9**
7.45 ± 0.93
200 mg kg−1
930.9 ± 113.8
380.1 ± 84.4*
9.54 ± 1.76
Sulfasalazine
1006.2 ± 87.0*
419.8 ± 80.1*
9.02 ± 1.56
Data are expressed as mean ± SEM. *P < .05, **P < .01 versus TNBS control group.
