Intestinal Anti-Inflammatory Activity of Baccharis dracunculifolia in the Trinitrobenzenesulphonic Acid Model of Rat Colitis
Table 5
Effects of B. dracunculifolia extract (5 and 50 mg kg−1) and sulfasalazine (25 mg kg−1) on GSH content, MPO activity and AP activity in TNBS chronic colitis with relapse
Group
GSH content (nmol g−1 tissue)
MPO activity (U g−1 tissue)
AP activity (mU mg−1 protein)
1 week
Non-colitic
2357.6 ± 311.3*
127.6 ± 14.5**
4.20 ± 0.36**
TNBS control
1590.1 ± 53.6
1045.2 ± 231.2
19.15 ± 4.38
B. dracunculifolia 5 mg kg−1
2386.1 ± 177.1*
221.1 ± 59.2*
7.93 ± 1.13**
B. dracunculifolia 50 mg kg−1
2218.6 ± 97.4*
167.6 ± 12.7*
8.31 ± 1.51**
Sulfasalazine 25 mg kg−1
1992.2 ± 254.2
951.0 ± 328.0
7.45 ± 0.92**
2 week
Non-colitic
2233.9 ± 192.5
115.9 ± 12.9
5.79 ± 0.70**
TNBS control
1881.3 ± 146.8
220.6 ± 42.9
13.31 ± 1.65
B. dracunculifolia 5 mg kg−1
2228.3 ± 132.7*
167.5 ± 31.7
8.39 ± 1.07*
B. dracunculifolia 50 mg kg−1
2538.2 ± 132.8**
178.5 ± 34.6
8.78 ± 1.13*
Sulfasalazine 25 mg kg−1
1776.6 ± 63.5
262.4 ± 59.4
11.20 ± 1.29
Data are expressed as mean ± SEM.
*
P < .05, **P < .01 versus TNBS control group.
