Protective Effect of Anthocyanins Extract from Blueberry on TNBS-Induced IBD Model of Mice
Figure 2
(a) Effects of anthocyanins extract on body weight in mice with TNBS-induced colitis. TNBS-induced colitis resulted in the loss of animal body weight, and the body weight varied during the administration of different doses (10, 20 and 40 mg kg-1) of anthocyanins, TNBS or vehicle in 6 days. The data were expressed as mean SEM. P-values were calculated using repeated measures ANOVA. A, differences between the groups; B, differences over time; and AB, differences between the interaction of experiment and time. Pairwise comparisons between the groups at individual time points were conducted by ANOVA and LSD post hoc test. On Days 1, 2 and 3, all pairwise comparisons between the groups had significant differences, except 10 and 20 mg kg-1 groups (P < .001). On Days 4, 5 and 6, all pairwise comparisons between the groups had significant differences (P < .001). (b) Effects of anthocyanins extract on the survival rate in mice with TNBS-induced colitis. TNBS-induced colitis resulted in animal death in the whole experiment course when compared with the TNBS-group mice that were given 20 and 40 mg kg-1 anthocyanins extract, which showed much less mortality rate.
