Figure 6: A hypothetical model to explain how adopting a low-fat, high-fiber diet and daily exercise might reduce the risk for PCa by reducing prostate inflammation and IGF-I/insulin signaling, IGF-I, insulin-like growth factor-I; PI3 kinase, phosphatidylinositol-3 kinase; Akt, protein kinase B; MAPK, mitogen-activated protein kinase (p38); COX-2, cyclooxygenase-2; ROS, reactive oxygen species; IL-1, interlukin-1, TNFα, tumor necrosis factor-alpha.